SLC11A1

SLC11A1
Solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Identifiers
Symbols SLC11A1; LSH; NRAMP; NRAMP1
External IDs OMIM600266 MGI1345275 HomoloGene73884 GeneCards: SLC11A1 Gene
RNA expression pattern
PBB GE SLC11A1 210423 s at tn.png
PBB GE SLC11A1 210422 x at tn.png
PBB GE SLC11A1 217473 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6556 18173
Ensembl ENSG00000018280 ENSMUSG00000026177
UniProt P49279 n/a
RefSeq (mRNA) NM_000578 NM_013612.2
RefSeq (protein) NP_000569 NP_038640.2
Location (UCSC) Chr 2:
219.25 – 219.26 Mb
Chr 1:
74.42 – 74.43 Mb
PubMed search [1] [2]

Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.[1][2][3]

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[3]

See also

References

Further reading

see also solute carrier disorders
B memb: cead, trns (1A, 1C, 1F, 2A, 3A1, 3A2-3, 3D), othr

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