Isoleucine-tRNA ligase


Isoleucine-tRNA ligase

In enzymology, an isoleucine-tRNA ligase (EC number|6.1.1.5) is an enzyme that catalyzes the chemical reaction

:ATP + L-isoleucine + tRNAIle ightleftharpoons AMP + diphosphate + L-isoleucyl-tRNAIle

The 3 substrates of this enzyme are ATP, L-isoleucine, and tRNA(Ile), whereas its 3 products are AMP, diphosphate, and L-isoleucyl-tRNA(Ile).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-isoleucine:tRNAIle ligase (AMP-forming). Other names in common use include isoleucyl-tRNA synthetase, isoleucyl-transfer ribonucleate synthetase, isoleucyl-transfer RNA synthetase, isoleucine-transfer RNA ligase, isoleucine-tRNA synthetase, and isoleucine translase. This enzyme participates in valine, leucine and isoleucine biosynthesis and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1FFY, PDB link|1JZQ, PDB link|1JZS, PDB link|1QU2, PDB link|1QU3, PDB link|1UDZ, PDB link|1UE0, PDB link|1WK8, PDB link|1WNY, and PDB link|1WNZ.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9030-96-0."

Gene Ontology (GO) codes


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