Adenosine monophosphate


Adenosine monophosphate
Adenosine monophosphate
Identifiers
CAS number 61-19-8 YesY
ChemSpider 5858 YesY
UNII 415SHH325A YesY
DrugBank DB00131
KEGG C00020 YesY
MeSH Adenosine+monophosphate
ChEBI CHEBI:16027 YesY
ChEMBL CHEMBL752 YesY
IUPHAR ligand 2455
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C10H14N5O7P
Molar mass 347.22 g/mol
Acidity (pKa) 0.9, 3.8, 6.1
 YesY monophosphate (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine. As a substituent it takes the form of the prefix adenylyl-.

Contents

Production and degradation

AMP can be produced during ATP synthesis by the enzyme adenylate kinase by combining two ADP molecules:

2 ADP → ATP + AMP

Or AMP may be produced by the hydrolysis of one high energy phosphate bond of ADP:

ADP → AMP + Pi

AMP can also be formed by hydrolysis of ATP into AMP and pyrophosphate:

ATP → AMP + PPi

When RNA is broken down by living systems, nucleoside monophosphates, including adenosine monophosphate, are formed.

AMP can be regenerated to ATP as follows:

AMP + ATP → 2 ADP (adenylate kinase in the opposite direction)
ADP + Pi → ATP (this step is most often performed in aerobes by the ATP synthase during oxidative phosphorylation)

AMP can be converted into IMP by the enzyme myoadenylate deaminase, freeing an ammonia group.

In a catabolic pathway, adenosine monophosphate can be converted to uric acid, which is excreted from the body.

cAMP

AMP can also exist as a cyclic structure known as cyclic AMP (or cAMP). Within certain cells the enzyme adenylate cyclase makes cAMP from ATP, and typically this reaction is regulated by hormones such as adrenaline or glucagon. cAMP plays an important role in intracellular signaling.

See also

References

External links


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Look at other dictionaries:

  • Adénosine monophosphate — Structure de l adénosine monophosphate …   Wikipédia en Français

  • adenosine monophosphate — adenosine monophosphate. См. АМФ. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • adenosine monophosphate — [män΄ō fäs′fāt΄] n. AMP …   English World dictionary

  • adenosine monophosphate — adenosine 5 monophosphate Abbreviation: AMP See: adenylic acid, adenosine triphosphate …   Glossary of Biotechnology

  • adenosine monophosphate — adenosine mo·no·phos·phate .män ə fäs .fāt, .mō nə n AMP * * * see AMP * * * (AMP) a nucleotide, the 5′ phosphate of adenosine, involved in energy metabolism; it is produced by hydrolysis of ATP and converted to ADP by adenylate kinase.… …   Medical dictionary

  • adenosine monophosphate — noun a nucleotide, found in all animal muscle cells, reversibly convertible to adenosine diphosphate and adenosine triphosphate …   Wiktionary

  • adenosine monophosphate — noun Date: 1950 amp …   New Collegiate Dictionary

  • Adenosine monophosphate — …   Википедия

  • adenosine monophosphate — A compound of importance in the release of energy for cellular activity, composed of adenine, d ribose and phosphoric acid; also called AMP, adenylic acid, adenine ribotide …   Dictionary of invertebrate zoology

  • adenosine monophosphate — See AMP, cAMP …   Dictionary of molecular biology


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