Glutamate-tRNA ligase


Glutamate-tRNA ligase

In enzymology, a glutamate-tRNA ligase (EC number|6.1.1.17) is an enzyme that catalyzes the chemical reaction

:ATP + L-glutamate + tRNAGlu ightleftharpoons AMP + diphosphate + L-glutamyl-tRNAGlu

The 3 substrates of this enzyme are ATP, L-glutamate, and tRNA(Glu), whereas its 3 products are AMP, diphosphate, and L-glutamyl-tRNA(Glu).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-glutamate:tRNAGlu ligase (AMP-forming). Other names in common use include glutamyl-tRNA synthetase, glutamyl-transfer ribonucleate synthetase, glutamyl-transfer RNA synthetase, glutamyl-transfer ribonucleic acid synthetase, glutamate-tRNA synthetase, and glutamic acid translase. This enzyme participates in 3 metabolic pathways: glutamate metabolism, porphyrin and chlorophyll metabolism, and aminoacyl-trna biosynthesis.

tructural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1FYJ, PDB link|1G59, PDB link|1J09, PDB link|1N75, PDB link|1N77, PDB link|1N78, PDB link|2CFO, PDB link|2CUZ, PDB link|2CV0, PDB link|2CV1, PDB link|2CV2, PDB link|2DXI, PDB link|2HRA, PDB link|2HRK, PDB link|2HSM, and PDB link|2O5R.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9068-76-2."

Gene Ontology (GO) codes


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