Citrate (pro-3S)-lyase

Citrate (pro-3S)-lyase
citrate (pro-3S)-lyase
Identifiers
EC number 4.1.3.6
CAS number 9012-83-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a citrate (pro-3S)-lyase (EC 4.1.3.6) is an enzyme that catalyzes the chemical reaction

citrate \rightleftharpoons acetate + oxaloacetate

Hence, this enzyme has one substrate, citrate, and two products, acetate and oxaloacetate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate). Other names in common use include citrase, citratase, citritase, citridesmolase, citrate aldolase, citric aldolase, citrate lyase, citrate oxaloacetate-lyase, and citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]. This enzyme participates in citrate cycle (tca cycle) and two-component system - general.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1U5H, 1U5V, 1Z6K, and 2HJ0.

References

  • DAGLEY S, DAWES EA (1955). "Citridesmolase: its properties and mode of action". Biochim. Biophys. Acta. 17 (2): 177–84. doi:10.1016/0006-3002(55)90348-6. PMID 13239657. 
  • Dimroth P, Loyal R, Eggerer H (1977). "Characterization of the isolated transferase subunit of citrate lyase as a CoA-Transferase. Evidence against a covalent enzyme-substrate intermediate". Eur. J. Biochem. 80 (2): 479–88. doi:10.1111/j.1432-1033.1977.tb11903.x. PMID 336371. 
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