- Transcription Factor II F
protein
Name = general transcription factor IIF, polypeptide 1, 74kDa
caption =
width =
HGNCid = 4652
Symbol =GTF2F1
AltSymbols = TFIIF, BTF4, RAP74
EntrezGene = 2962
OMIM = 189968
RefSeq = NM_002096
UniProt = P35269
PDB =
ECnumber =
Chromosome = 19
Arm = p
Band = 13.3
LocusSupplementaryData = protein
Name = general transcription factor IIF, polypeptide 2, 30kDa
caption =
width =
HGNCid = 4653
Symbol =GTF2F2
AltSymbols = TFIIF, BTF4, RAP30
EntrezGene = 2963
OMIM = 189969
RefSeq = NM_004128
UniProt = P13984
PDB =
ECnumber =
Chromosome = 13
Arm = q
Band = 14
LocusSupplementaryData = protein
Name = general transcription factor IIF, polypeptide 2-like
caption =
width =
HGNCid = 4654
Symbol = GTF2F2L
AltSymbols = TFIIF
EntrezGene = 2964
OMIM =
RefSeq = NG_003013
UniProt =
PDB =
ECnumber =
Chromosome = 4
Arm = q
Band = 31.22
LocusSupplementaryData =Transcription Factor II F (TFIIF) is one of several
general transcription factor s that make up theRNA polymerase II preinitiation complex .cite book | author = Lewin, Benjamin | title = Genes VIII | publisher = Pearson Prentice Hall | location = Upper Saddle River, NJ | year = 2004 | pages = p636-637 | isbn = 0-13-144946-X | oclc = | doi = ]Transcription Factor II F is encoded by the gene|GTF2F1, gene|GTF2F2, and gene|GTF2F2L genes.cite journal | author = Finkelstein A, Kostrub CF, Li J, Chavez DP, Wang BQ, Fang SM, Greenblatt J, Burton ZF | title = A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II | journal = Nature | volume = 355 | issue = 6359 | pages = 464–7 | year = 1992 | pmid = 1734284 | doi = 10.1038/355464a0 | issn = ] cite journal | author = Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC | title = Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome | journal = Hum. Mol. Genet. | volume = 3 | issue = 1 | pages = 61–4 | year = 1994 | pmid = 8162052 | doi = | issn = ] cite journal | author = Purrello M, Di Pietro C, Rapisarda A, Mirabile E, Motta S, Sichel G, Grzeschik KH | title = Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens | journal = Cytogenet. Cell Genet. | volume = 69 | issue = 1-2 | pages = 75–80 | year = 1995 | pmid = 7835093 | doi = | issn = ]
DNA is thought to be wrapped one complete turn around the preinitiation complex and it is TFIIF that helps keep this tight wrapping.cite journal | author = Lee TI, Young RA | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77] In the process, the torsional strain on the DNA may aid inDNA melting at thepromoter , forming thetranscription bubble . Of all the general transcription factors, TFIIF is the most similar to bacterialsigma factor .See also
*
TFIIA
*TFIIB
*TFIID
*TFIIE References
External links
*
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