Colcemid

Colcemid

Used in cytogenetics, colcemid, also known as demecolcine, is related to colchicine but it is less toxic. It depolymerises microtubules and limits microtubule formation (inactivates spindle fibre formation), thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed.

Mechanism of Action

Colcemid is a microtubule-depolymerizing drug like vinblastine. It acts by two distinct mechanisms. At very low concentration it binds to microtubule plus end to suppress microtubule dynamics.[1] Recent study has found at higher concentration colcemid can promote microtubule detachment from microtubule organizing center. Detached microtubules with unprotected minus end depolymerizes with time. Cytotoxicity of the cells seems to correlate better with microtubule detachment.[2] Lower concentration affects microtubule dynamics and cell migration.[2]

References

  1. ^ Jordan, Mary Ann; Wilson, Leslie (2004). "Microtubules as a target for anticancer drugs". Nature reviews. Cancer 4 (4): 253–65. doi:10.1038/nrc1317. PMID 15057285. 
  2. ^ a b Yang, Hailing; Ganguly, Anutosh; Cabral, Fernando (2010). "Inhibition of Cell Migration and Cell Division Correlates with Distinct Effects of Microtubule Inhibiting Drugs". The Journal of biological chemistry 285 (42): 32242–50. doi:10.1074/jbc.M110.160820. PMC 2952225. PMID 20696757. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2952225. 

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  • colcemid — colcemid. См. колцемид. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • colcemid — Methylated derivative of colchicine …   Dictionary of molecular biology

  • colcemid — noun A derivative of colchicine that is used in genetic research …   Wiktionary

  • колцемид — colcemid колцемид. Cинтетический аналог колхицина <colchicine>, используемый для ингибирования деления клеток на стадии метафазы, обладает более “мягким” действием (менее кластогенен), чем колхицин. (Источник: «Англо русский толковый… …   Молекулярная биология и генетика. Толковый словарь.

  • LOAEL — Unter der Toxizitätsbestimmung versteht man die Feststellung der Giftigkeit oder Schädlichkeit eines Stoffes. Die Toxizitätsbestimmung beruht auf Methoden, die von den zuständigen internationalen Stellen (insbesondere der OECD) anerkannt und… …   Deutsch Wikipedia

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  • Demecolcine — Systematic (IUPAC) name (S) 1,2,3,10 Tetramethoxy 7 methylamino 6,7 dihydro 5H benzo[a]heptalen 9 one Clinical data Pregnancy cat …   Wikipedia

  • Cytogenetics — A metaphase cell positive for the bcr/abl rearrangement using FISH For the scientific journal of this title, see Cytogenetics and Genome Research. Cytogenetics is a branch of genetics that is concerned with the study of the structure and function …   Wikipedia

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