ImageFile = Succinyl-CoA.png
ImageSize = 150px
Section1 = Chembox Identifiers
CASNo = 604-98-8
PubChem = 1111
MeSHName = succinyl-coenzyme+A
Section2 = Chembox Properties
Formula = C25H40N7O19P3S
MolarMass = 867.608
Section3 = Chembox Hazards
Succinyl-Coenzyme A, generally abbreviated as Succinyl-CoA or SucCoA is a combination of
succinic acidand coenzyme A.
It is an important intermediate in the
citric acid cycle, where it is synthesized from α-Ketoglutarate by α-ketoglutarate dehydrogenase through decarboxylation. During the process, coenzyme Ais added.
It is also synthesized from propionyl CoA, the odd numbered fatty acid which cannot undergo beta-oxidation. [cite journal |author=Halarnkar PP, Blomquist GJ |title=Comparative aspects of propionate metabolism |journal=Comp. Biochem. Physiol., B |volume=92 |issue=2 |pages=227–31 |year=1989 |pmid=2647392] Propionyl-CoA is carboxylated to D-methylmalonyl-CoA, isomerized to L-methylmalonyl-CoA, and rearranged to yield succinyl-CoA via a vitamin B12-dependent enzyme. Succinyl-CoA is an intermediate of the citric acid cycle and can be readily incorporated there.
Succinyl CoA can be formed from methylmalonyl CoA through the utilization of deoxyadenosyl-B12 (deoxyadenosylcobalamin) by methylmalonyl CoA Mutase. This reaction, which requires
vitamin B12to occur, is important in the catabolism of some branched-chain amino acids as well as odd-chain fatty acids.
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Look at other dictionaries:
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succinyl-CoA ligase — SYN: succinyl CoA synthetase … Medical dictionary
succinyl CoA synthetase — suc·ci·nyl CoA syn·the·tase (sukґsĭ nəl ko aґ sinґthə tās) succinate CoA ligase (GDP forming) … Medical dictionary
Succinyl-coenzyme A — Structure de la succinyl coenzyme A. Général No CAS … Wikipédia en Français