Succinyl coenzyme A synthetase


Succinyl coenzyme A synthetase

Succinyl coenzyme A synthetase (succinate thiokinase) catalyzes the formation of succinate and coenzyme-A, a 4-carbon metabolite, from succinyl-CoA.

Reaction

Succinyl-CoA synthetase catalyzes a reversible step in the citric acid cycle, which involves the substrate-level phosphorylation of GDP.

Isoforms

Johnson et al. describe two isoforms of succinyl-CoA synthetase in mammals, one that specifically uses ATP for synthesis, and one that utilizes GTP. [cite journal | author=Johnson JD, Mehus JG, Tews K, Milavetz BI, Lambeth DO| title=Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes| journal=J Biol Chem| year=1998 |url=http://www.jbc.org/cgi/content/full/273/42/27580| pages=27580–6 |volume=273 |issue=42| doi=10.1074/jbc.273.42.27580]

* - ADP-forming - Gene|SUCLA2
* - GDP-forming - Gene|SUCLG1, Gene|SUCLG2

The GTP form is the one more commonly used in the human citric acid cycle. Fact|date=November 2007

tructure

The crystal structure of Succinyl-CoA synthetase alpha subunit (ATP-binding isoform) was determined by Joyce et al. to a resolution of 2.10 A, with PDB code 1CQJ. [http://www.rcsb.org/pdb/explore.do?structureId=1CQJ] . [Joyce, M. A., Fraser, M. E., James, M. N. G., Bridger, W. A., and Wolodko, W. T. (2000) Biochemistry 39, 17-25]

References

External links

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