Alpha 1-antichymotrypsin


Alpha 1-antichymotrypsin

Alpha 1-antichymotrypsin is an alpha globulin glycoprotein that is a member of the serine proteinase inhibitor (serpin) family.

It inhibits the activity of certain enzymes called proteinases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation. This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes.cite journal |author=Kalsheker N |title=Alpha 1-antichymotrypsin |journal=Int. J. Biochem. Cell Biol. |volume=28 |issue=9 |pages=961–4 |year=1996 |pmid=8930118]

This enzyme is produced in the liver, and is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [cite web | title = Entrez Gene: SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=12| accessdate = ]

Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease.

References

Further reading

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citations =
*cite journal | author=Janciauskiene S, Wright HT |title=Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease. |journal=Bioessays |volume=20 |issue= 12 |pages= 1039–46 |year= 1999 |pmid= 10048303 |doi= 10.1002/(SICI)1521-1878(199812)20:12<1039::AID-BIES10>3.0.CO;2-Z |doilabel=10.1002/(SICI)1521-1878(199812)20:121039::AID-BIES103.0.CO;2-Z
*cite journal | author=Kalsheker N, Morley S, Morgan K |title=Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1-antichymotrypsin. |journal=Biochem. Soc. Trans. |volume=30 |issue= 2 |pages= 93–8 |year= 2002 |pmid= 12023832 |doi= 10.1042/

External links

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