Anabasine

Anabasine

Chembox new
Name = Anabasine
ImageFile = Anabasin.svg
ImageName = Chemical structure of anabasine
Section1 = Chembox Identifiers
CASNo = 40774-73-0
SMILES = [H] [C@@] 2(N(C)CCC2)c1cccnc1

Section2 = Chembox Properties
Formula = C10H14N2
MolarMass = 162.23 g/mol
Density = 1.01 g/ml
MeltingPt = 9 °C
BoilingPt = 270 °C

Section7 = Chembox Hazards
FlashPt = 93 °C
ExternalMSDS = [http://www.coleparmer.com/catalog/Msds/02161.htm External MSDS]

Anabasine is a pyridine alkaloid found in the Tree Tobacco ("Nicotiana glauca") plant, a close relative of the common tobacco plant ("Nicotiana tabacum"). It is similar to nicotine. Its principal (historical) industrial use is as an insecticide.

Anabasine is present in trace amounts in tobacco smoke, and can be used as an indicator of a person's exposure to tobacco smoke. [cite journal | author = P. Jacob, 3rd, L. Yu, A. T. Shulgin and N. L. Benowitz | title = Minor tobacco alkaloids as biomarkers for tobacco use: comparison of users of cigarettes, smokeless tobacco, cigars, and pipes | year = 1999 | journal = Am J Public Health | volume = 89 | issue = 5 | pages = 731–736 | url = http://www.ajph.org/cgi/content/abstract/89/5/731 | pmid = 10224986]

Pharmacology

Anabasine is a nicotinic acetylcholine receptor agonist. In high doses, it produces a depolarizing block of nerve transmission, which can cause symptoms similar to those of nicotine poisoning and, ultimately, death by asystole. [cite journal | title = Fatal poisoning from nicotiana glauca leaves: identification of anabasine by gas-chromatography/mass spectrometry | | author = Mizrachi, N.; Levy, S.; Goren, Z. | journal = Journal of Forensic Sciences | volume = 45 | issue = 3 | year = 2000 | pages = 736–741 | pmid = 10855991] In larger amounts it is thought to be teratogenic in swine. [cite web
title = Notes on poisoning: Nicotiana tabacum
work = Canadian Biodiversity Information Facility
publisher = Government of Canada
date = 2008-03-18
url = http://www.cbif.gc.ca/pls/pp/ppack.info?p_psn=186&p_type=all&p_sci=sci&p_x=px
accessdate = 2008-05-01
]

The intravenous LD50 of anabasine ranges from 11 mg/kg to 16 mg/kg in mice, depending on the enantiomer.cite web
last = Stephen
first = Lee
coauthors = Wildeboer, Kristin; Panter, Kip; Kem, William; Gardner, Dale; Molyneux, Russell; Chang, Cheng-Wei; Soti, Ferenc; Pfister, James
title = Neurotoxicology and Teratology
publisher = USDA
date = 2006-02-20
url = http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=182063&pf=1
accessdate = 2008-05-01
]

ee also

*Psychoactive drug
*Addiction
*Nicotine poisoning

References


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  • anabasine — anabazinas statusas T sritis chemija apibrėžtis Alkaloidas. formulė C₅H₄NC₅H₁₀N atitikmenys: angl. anabasine rus. анабазин ryšiai: sinonimas – (S) 3 (2 piperidinil) piridinas …   Chemijos terminų aiškinamasis žodynas

  • anabasine — /euh nab euh seen , sin/, n. Chem. a colorless, poisonous liquid, C10H14N2, used as an insecticide. [ < NL Anabas(is) genus name (see ANA , BASIS) + INE2] * * * …   Universalium

  • anabasine — noun A pyridine alkaloid similar to nicotine, found in Nicotiana glauca, a close relative of the common tobacco plant, formerly used as an insecticide …   Wiktionary

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  • anabasine — n. insecticide …   English contemporary dictionary

  • anabasine — anab·a·sine …   English syllables

  • anabasine — əˈnabəˌsēn, sə̇n noun ( s) Etymology: New Latin Anabasis (genus name of Anabasis aphylla) + English ine : an insecticidal liquid alkaloid (C5H4N) C5H10N related to nicotine and found in tobacco and in a nearly leafless subshrub (Anabasis aphylla) …   Useful english dictionary

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