Adipocyte protein 2

protein
Name = fatty acid binding protein 4, adipocyte

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width =
caption = Crystallographic structure (PDB|2HNX) of palmitic acid (white sticks) complexed with aP2 (beta sheets = green, alpha helices = red, loops = cyan)
Symbol = FABP4
AltSymbols = A-FABP
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ATC_suffix=
ATC_supplemental=
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DrugBank=
EntrezGene = 2167
HGNCid = 3559
OMIM = 600434
PDB = 2HNX
RefSeq = NM_001442
UniProt = P15090
ECnumber =
Chromosome = 8
Arm = q
Band = 21
LocusSupplementaryData =

aP2 (adipocyte Protein 2)cite journal | author = Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA | title = Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA | journal = Biochemistry | volume = 28 | issue = 22 | pages = 8683–90 | year = 1989 | pmid = 2481498 | doi = 10.1021/bi00448a003 | issn = ] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs [ [http://www.forbes.com/forbeslife/health/feeds/hscout/2006/07/14/hscout533816.html Forbes health article July 14 2006] ] [ [http://www.medicinenet.com/script/main/art.asp?articlekey=62919 Medicinenet.com] ] has the possibility of treating heart disease,cite journal | author = Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF | title = Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis | journal = Nat. Med. | volume = 7 | issue = 6 | pages = 699–705 | year = 2001 | pmid = 11385507 | doi = 10.1038/89076 | issn = ] diabetes,cite journal | author = Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS | title = Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2 | journal = Nature | volume = 447 | issue = 7147 | pages = 959–65 | year = 2007 | pmid = 17554340 | doi = 10.1038/nature05844 | issn = ] asthma,cite journal | author = Shum BO, Mackay CR, Gorgun CZ, Frost MJ, Kumar RK, Hotamisligil GS, Rolph MS | title = The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation | journal = J. Clin. Invest. | volume = 116 | issue = 8 | pages = 2183–2192 | year = 2006 | pmid = 16841093 | doi = 10.1172/JCI24767 | issn = ] obesity,cite journal | author = Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS | title = Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes | journal = Cell Metab. | volume = 1 | issue = 2 | pages = 107–19 | year = 2005 | pmid = 16054052 | doi = 10.1016/j.cmet.2004.12.008 | issn = ] and fatty liver disease.cite journal | author = Makowski L, Hotamisligil GS | title = The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis | journal = Curr. Opin. Lipidol. | volume = 16 | issue = 5 | pages = 543–8 | year = 2005 | pmid = 16148539 | doi = | issn = ]

See also

* Fatty acid-binding protein

References

External links

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