Nullification may refer to:
- Nullification (U.S. Constitution), a legal theory that a U.S. State has the right to nullify, or invalidate, any federal law that a state has deemed unconstitutional.
- Nullification Crisis, the 1832 confrontation between the United States government and the state of South Carolina over the latter's attempt to nullify a federal law.
- Jury nullification, a legal term that refers to a jury's ability to deliver a verdict knowingly in contradiction to written law.
- Nullification, a form of body modification involving the voluntary removal of body parts
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