Hypoaldosteronism

Hypoaldosteronism
Hypoaldosteronism
Classification and external resources

Aldosterone
ICD-10 E27.4
DiseasesDB 20960
MeSH D006994

In medicine (endocrinology), hypoaldosteronism refers to decreased levels of the hormone aldosterone.

The term "isolated hypoaldosteronism" is used to describe lowered aldosterone without corresponding changes in cortisol.[1] (The two hormones are both produced by the adrenals.)

Contents

Causes

There are several causes for this condition, including primary adrenal insufficiency, congenital adrenal hyperplasia, and medications (certain diuretics, NSAIDs, and ACE inhibitors).

  1. Primary adrenal insufficiency
  2. Congenital adrenal hyperplasia (21 and 11β but not 17)
  3. Aldosterone synthase deficiency
  • Hyporeninemic hypoaldosteronism (due to decreased angiotensin 2 production as well as intra-adrenal dysfunction)[2]
  1. Renal dysfunction-most commonly diabetic nephropathy
  1. ACE inhibitors
  2. NSAIDs
  3. Cyclosporine

Treatment

Effects

This condition may result in hyperkalemia, when it is sometimes termed 'type 4 renal tubular acidosis' even though it doesn't actually cause acidosis. It can also cause urinary sodium wasting, leading to volume depletion and hypotension.

Na+ is lost in the urine. K+ is retained, and the plasma K+ rises.

When adrenal insufficiency develops rapidly, the amount of Na+ lost from the extracellular fluid exceeds the amount excreted in the urine, indicating that Na+ also must be entering cells. When the posterior pituitary is intact, salt loss exceeds water loss, and the plasma Na+ falls. However, the plasma volume also is reduced, resulting in hypotension, circulatory insufficiency, and, eventually, fatal shock. These changes can be prevented to a degree by increasing the dietary NaCl intake. Rats survive indefinitely on extra salt alone, but in dogs and most humans, the amount of supplementary salt needed is so large that it is almost impossible to prevent eventual collapse and death unless mineralocorticoid treatment is also instituted

See also

References

  1. ^ Becker, Kenneth L. (2001). Principles and practice of endocrinology and metabolism. Lippincott Williams & Wilkins. pp. 785–. ISBN 9780781717502. http://books.google.com/books?id=FVfzRvaucq8C&pg=PA785. Retrieved 15 July 2011. 
  2. ^ a b DeFronzo RA (1980). "Hyperkalemia and hyporeninemic hypoaldosteronism". Kidney Int. 17 (1): 118–34. doi:10.1038/ki.1980.14. PMID 6990088. 
  3. ^ Sebastian A, Schambelan M, Sutton JM (1984). "Amelioration of hyperchloremic acidosis with furosemide therapy in patients with chronic renal insufficiency and type 4 renal tubular acidosis". Am. J. Nephrol. 4 (5): 287–300. doi:10.1159/000166827. PMID 6524600. 



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