MFGE8

MFGE8
Milk fat globule-EGF factor 8 protein
Identifiers
Symbols MFGE8; BA46; EDIL1; HMFG; HsT19888; MFG-E8; MFGM; OAcGD3S; SED1; SPAG10; hP47
External IDs OMIM602281 MGI102768 HomoloGene4334 GeneCards: MFGE8 Gene
RNA expression pattern
PBB GE MFGE8 210605 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4240 17304
Ensembl ENSG00000140545 ENSMUSG00000030605
UniProt Q08431 Q3U8S9
RefSeq (mRNA) NM_001114614.1 NM_001045489
RefSeq (protein) NP_001108086.1 NP_001038954
Location (UCSC) Chr 15:
89.44 – 89.46 Mb
Chr 7:
86.28 – 86.29 Mb
PubMed search [1] [2]

Milk fat globule-EGF factor 8 protein Mfge8), also known as lactadherin, is a protein which in humans is encoded by the MFGE8 gene.[1][2]

Contents

Species distribution

Mfge8 is secreted protein found in vertebrates, including mammals as well as birds.

Function

Mfge8 contains a phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. Mfge8 binds PS, which is exposed on the surface of apoptotic cells. Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.

References

  1. ^ "Entrez Gene: MFGE8 milk fat globule-EGF factor 8 protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4240. 
  2. ^ Collins C, Nehlin JO, Stubbs JD, Kowbel D, Kuo WL, Parry G (January 1997). "Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25". Genomics 39 (1): 117–8. doi:10.1006/geno.1996.4425. PMID 9027496. 

Further reading



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Look at other dictionaries:

  • Mfge8 — La Milk fat globule EGF factor 8 protein (MFGE8), également connue sous le nom de lactadhérine, est une protéine encodée par le gène MFGE8[1]. Répartition La protéine Mfge8 est secrétée chez les vertébrés (y compris les mammifères et les oiseaux) …   Wikipédia en Français

  • Фолликулярные дендритные клетки — (ФДК) клетки иммунной системы, находящиеся в первичных и вторичных фолликулах лимфатической ткани. [1] Впервые ФДК были обнаружены в 1965 году и, благодаря большому количеству древовидных отростков на своей поверхности, были отнесены к группе… …   Википедия

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  • EGF-like domain — Pfam box Symbol = EGF Name = EGF like domain width = caption = Pfam= PF00008 InterPro= IPR006209 SMART= PROSITE = PDOC00021 SCOP = 1apo TCDB = OPM family= OPM protein= 1dan PDB=PDB3|1tpg :86 119 PDB3|1haf :182 221 PDB3|1hae :182 221PDB3|1hrf :182 …   Wikipedia

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