P2RX1

P2RX1
Purinergic receptor P2X, ligand-gated ion channel, 1
Identifiers
Symbols P2RX1; P2X1
External IDs OMIM600845 MGI1098235 HomoloGene1921 GeneCards: P2RX1 Gene
RNA expression pattern
PBB GE P2RX1 210401 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5023 18436
Ensembl ENSG00000108405 ENSMUSG00000020787
UniProt P51575 Q91WI3
RefSeq (mRNA) NM_002558.2 NM_008771.3
RefSeq (protein) NP_002549.1 NP_032797.3
Location (UCSC) Chr 17:
3.8 – 3.82 Mb
Chr 11:
72.81 – 72.83 Mb
PubMed search [1] [2]

P2X purinoceptor 1 is a protein that in humans is encoded by the P2RX1 gene.[1]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Expressed in smooth muscle and platelets. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.[2]

Contents

See also

References

  1. ^ Valera S, Talabot F, Evans RJ, Gos A, Antonarakis SE, Morris MA, Buell GN (Nov 1996). "Characterization and chromosomal localization of a human P2X receptor from the urinary bladder". Receptors Channels 3 (4): 283–9. PMID 8834001. 
  2. ^ "Entrez Gene: P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5023. 

Further reading

External links

Ionotropic glutamates ATP-gated channels B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

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Look at other dictionaries:

  • P2X purinoreceptor — ATP P2X receptor Identifiers Symbol P2X receptor Pfam PF00864 InterPro …   Wikipedia

  • Ligand-gated ion channel — Neurotransmitter gated ion channel transmembrane region Ligand gated ion channel Identifiers Symbol Neur chan memb Pfam …   Wikipedia

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