Sodium salicylate

Sodium salicylate
Sodium salicylate
Identifiers
CAS number 54-21-7 YesY
PubChem 5900
ChemSpider 5689 YesY
UNII WIQ1H85SYP YesY
EC number 200-198-0
DrugBank DB01398
KEGG D00566
RTECS number VO5075000
Jmol-3D images Image 1
Properties
Molecular formula C7H5NaO3
Molar mass 160.11 g/mol
Appearance White crystals
Melting point

200 °C

Solubility in water ~ 660 g/l at 20 °C
Hazards
R-phrases R22, R36/37/38
S-phrases S24/25, S26, S36/37/39
Main hazards Harmful
NFPA 704
NFPA 704.svg
1
1
0
Autoignition
temperature
> 250 °C
 YesY salicylate (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Sodium salicylate is a sodium salt of salicylic acid. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure. Historically, it has been synthesized from methyl salicylate (found in wintergreen plants or the bark of sweet birch tree) by reacting it with an excess of sodium hydroxide and heating it under reflux.[1]

Contents

Properties

Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.[citation needed]

Uses

It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells [2][3][4] and also necrosis.[5] It is also a potential replacement for aspirin for people sensitive to it.

References

  1. ^ Lehman, J.W., Operational Organich Chemistry, 4th ed., New Jersey, Prentice Hall, 2009
  2. ^ Klampfer, Lidija; Jörg Cammenga, Hans-Georg Wisniewski, Stephen D. Nimer (1999-04-01). "Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines". Blood 93 (7): 2386–94. PMID 10090950. http://bloodjournal.hematologylibrary.org/cgi/content/full/93/7/2386. Retrieved 2011-02-21. 
  3. ^ Rae, Colin; Susana Langa, Steven J. Tucker, David J. MacEwan (2007-07-31). "Elevated NF-κB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis". Proceedings of the National Academy of Sciences of the USA 104 (31): 12790–5. doi:10.1073/pnas.0701437104. PMC 1937545. PMID 17646662. http://www.pnas.org/content/104/31/12790. Retrieved 2011-02-21. 
  4. ^ Stark, Lesley A.; et al (2007-05). "Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer". Carcinogenesis 28 (5): 968–76. doi:10.1093/carcin/bgl220. PMID 17132819. http://carcin.oxfordjournals.org/content/28/5/968. Retrieved 2011-02-21. 
  5. ^ Schwenger, Paul; Edward Y. Skolnik, Jan Vilcek (1996-04-05). "Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate". The Journal of Biological Chemistry 271 (14): 8089–94. doi:10.1074/jbc.271.14.8089. PMID 8626494. http://www.jbc.org/content/271/14/8089. Retrieved 2011-02-21. 

External links


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Look at other dictionaries:

  • sodium salicylate — n a crystalline salt NaC7H5O3 that has a sweetish saline taste and is used chiefly as an analgesic, antipyretic, and antirheumatic * * * [USP] the monosodium salt of salicylic acid, used as an analgesic, antiinflammatory, antipyretic, and… …   Medical dictionary

  • sodium salicylate — A drug that is a type of nonsteroidal anti inflammatory drug. Sodium salicylate may be tolerated by people who are sensitive to aspirin …   English dictionary of cancer terms

  • sodium salicylate — noun Date: 1885 a crystalline salt NaC7H5O3 that has a sweetish saline taste and is used chiefly as an analgesic, antipyretic, and antirheumatic …   New Collegiate Dictionary

  • sodium salicylate — Chem. a white, crystalline compound, C7H5NaO3, soluble in water, alcohol, and glycerol: used in medicine as an analgesic, antipyretic, and anti inflammatory, and as a preservative. [1900 05] * * * …   Universalium

  • sodium salicylate — noun a crystalline salt used as an analgesic and antipyretic • Hypernyms: ↑analgesic, ↑anodyne, ↑painkiller, ↑pain pill * * * noun : a crystalline salt HOC6H4COONa with a sweetish saline taste used chiefly in medicine as an analgesic, antipyretic …   Useful english dictionary

  • salicylate — [ salisilat ] n. m. • 1844; de salicylique ♦ Chim. Sel ou ester de l acide salicylique. Salicylate de phénol (antiseptique). ⇒ salol. Salicylate de lithium. ● salicylate nom masculin Sel ou ester de l acide salicylique. ● salicylate (expressions) …   Encyclopédie Universelle

  • SALICYLATE DE SOUDE — Sel de sodium de l’acide salicylique. Obtenu par action de l’acide salicylique sur du bicarbonate de sodium, il se présente sous forme de cristaux incolores et inodores. Il est employé pour le traitement des affections rhumatismales …   Encyclopédie Universelle

  • Натрия Салицилат (Sodium Salicylate) — лекарственное вещество, по своему действию и побочным эффектам сходное с аспирином. Используется главным образом для лечения ревматической лихорадки. Источник: Медицинский словарь …   Медицинские термины

  • sodium — A metallic element, atomic no. 11, atomic wt. 22.989768; an alkali metal oxidizing readily in air or water; its salts are found in natural biologic systems and are extensively used in medicine and industry. The s. ion is the most plentiful… …   Medical dictionary

  • Methyl salicylate — Methyl salicylate …   Wikipedia

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