Ethisterone

Ethisterone

Drugbox
IUPAC_name = (8"R",9"S",10"R",13"R",14"S",17"R")-17-Ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1"H"-cyclopenta [a] phenanthren-3-one


CAS_number=434-03-7
ATC_prefix=G03
ATC_suffix=DC04
ATC_supplemental=
PubChem=11890120
DrugBank=
C = 21 | H = 28 | O = 2
molecular_weight = 312.446 g/mol
bioavailability=
metabolism =
elimination_half-life=
excretion =
pregnancy_category =
legal_status =
routes_of_administration=

Ethisterone is a progestogen hormone.

The first orally active progestin, ethisterone (pregneninolone, 17α-ethynyltestosterone), the 17α-ethynyl analog of testosterone, was synthesized in 1938 by Hans Herloff Inhoffen, Willy Logemann, Walter Hohlweg, and Arthur Serini at Schering AG in Berlin and marketed in Germany in 1939 as "Proluton C" and by Schering in the U.S. in 1945 as "Pranone".

Ethisterone was also marketed in the U.S. from the 1950s into the 1960s under a variety of trade names by other pharmaceutical companies that had been members of the pre-World War II European hormone cartel (Ciba, Organon, Roussel).

References

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* Kugener, André (2004). [http://www.kugener.com/abfrage.php?id=0081 Tabletten der Fa. Schering] ( [http://translate.google.com/translate?hl=en&sl=de&u=http://www.kugener.com/abfrage.php%3Fid%3D0081&sa=X&oi=translate&resnum=2&ct=result&prev=/search%3Fq%3Dproluton%2Bc%2B1939%26start%3D10%26hl%3Den%26rls%3Dcom.microsoft:en-US%26sa%3DN Tablets of Schering AG] ) "Proluton C" tablets circa 1939
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  • ethisterone — ethis·ter·one …   English syllables

  • ethisterone — ə̇ˈthistəˌrōn noun ( s) Etymology: ethinyl + testosterone : a synthetic crystalline orally effective female sex hormone C21H28O2 administered in cases of deficiency of progesterone; 17 ethynyl testosterone called also anhydrohydroxyprogesterone …   Useful english dictionary

  • Этистерон (Ethisterone) — синтетический женский половой гормон (см. Прогестоген), применяется (часто в сочетании с эстрогеном) для лечения нарушений менструального цикла, главным образом аменореи. Ранее использовался для тестирования на наличие у женщины беременности по… …   Медицинские термины

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  • pregneninolone — SYN: ethisterone. * * * preg·nen·in·o·lone .preg nen in əl .ōn n ETHISTERONE …   Medical dictionary

  • Djerassi , Carl — (1923–) American chemist Djerassi was born in the Austrian capital of Vienna, the son of a Bulgarian physician and an Austrian mother. As both parents were Jewish, Djerassi emigrated to America in 1939. He was educated at Kenyon College, Ohio,… …   Scientists

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