Cytoprotection

Cytoprotection is a process by which chemical compounds provide protection to cells against harmful agents.^[1]

For example, a gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing mucosal protection.^[2] Examples of gastric cyctoprotective agents include prostaglandins which protect the stomach mucosa against injury. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more susceptible in injury.^[3] Gastric cytoprotective drugs include carbenoxolone, deglycyrrhizinised liquorice, sucralfate (aluminium hydroxide and sulphated sucrose), misoprostol (a prostaglandin analogue) and bismuth chelate (tri-potassium di-citrato bismuthate).

References

1. ^ "MeSH Heading: Cytoprotection". Medical Subject Headings. United States National Library of Medicine. http://www.nlm.nih.gov/cgi/mesh/2009/MB_cgi?mode=&term=Cytoprotection. 
2. ^ Tulassay Z, Herszényi L (April 2010). "Gastric mucosal defense and cytoprotection". Best Pract Res Clin Gastroenterol 24 (2): 99–108. doi:10.1016/j.bpg.2010.02.006. PMID 20227024. 
3. ^ Wallace JL (September 1992). "Prostaglandins, NSAIDs, and cytoprotection". Gastroenterol. Clin. North Am. 21 (3): 631–41. PMID 1516961. 

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