Cytolethal distending toxin

Cytolethal distending toxin
Cytolethal distending toxin A/C family
PDB 1sr4 EBI.jpg
crystal structure of the haemophilus ducreyi cytolethal distending toxin
Identifiers
Symbol CDtoxinA
Pfam PF03498
Pfam clan CL0066
InterPro IPR003558

In molecular biology, cytolethal distending toxin (cdt) is a toxin produced by Proteobacteria, including Escherichia coli, Haemophilus spp and Campylobacter spp.This toxin causes distension in certain cell lines,[1][2] which eventually disintegrate and die. It consists of three subunits: A, B and C. Their sizes are approx. 27.7, 29.5 and 19.9kDa respectively,[1] and they appear to be entirely novel.[2] Further research on the complete toxin has revealed that it blocks the cell cycle at stage G2, through inactivation of the cyclin-dependent kinase Cdk1, and without induction of DNA breaks. This leads to multipolar abortive mitosis and micronucleation, associated with centrosomal amplification.[3] The roles of each subunit are unclear, but it is believed that they have separate roles in pathogenicity.

References

  1. ^ a b Pickett CL, Cottle DL, Pesci EC, Bikah G (March 1994). "Cloning, sequencing, and expression of the Escherichia coli cytolethal distending toxin genes". Infect. Immun. 62 (3): 1046–51. PMC 186222. PMID 8112838. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=186222. 
  2. ^ a b Eyigor A, Dawson KA, Langlois BE, Pickett CL (May 1999). "Cytolethal distending toxin genes in Campylobacter jejuni and Campylobacter coli isolates: detection and analysis by PCR". J. Clin. Microbiol. 37 (5): 1646–50. PMC 84865. PMID 10203548. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84865. 
  3. ^ De Rycke J, Sert V, Comayras C, Tasca C (March 2000). "Sequence of lethal events in HeLa cells exposed to the G2 blocking cytolethal distending toxin". Eur. J. Cell Biol. 79 (3): 192–201. PMID 10777111. 

This article includes text from the public domain Pfam and InterPro IPR003558


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Enterohämorrhagische Escherichia coli — Klassifikation nach ICD 10 A04 Sonstige bakterielle Darminfektionen A04.3 Darminfektion durch enterohämorrhagische Escherichia coli …   Deutsch Wikipedia

  • Aggregatibacter actinomycetemcomitans — is an oral commensal found also in severe infections in the oral cavity, mainly the periodontium. A. actinomycetemcomitans , previously Actinobacillus actinomycetemcomitans , is a gram negative facultative non motile rod. It is also associated… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”