Staphylococcal scalded skin syndrome

Staphylococcal scalded skin syndrome

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Staphylococcal scalded skin syndrome, SSSS, also known as Pemphigus neonatorum or Ritter's disease, is a dermatological condition caused by "Staphylococcus aureus".

Pathophysiology

The syndrome is induced by 2 epidermolytic exotoxins (exfoliatin) [DorlandsDict|three/000037652|exfoliatin] A and B, which are released by "S. aureus" and cause detachment within the the epidermal layer. One of the exotoxins is produced by the bacterial chromosome, while the other is produced by a plasmid. (Bacterial plasmids are pieces of self-replicating DNA that often code for secondary characteristics, such as antibiotic resistance, and toxin production.) These exotoxins are proteases that cleave desmoglein-1, which normally holds the granulosum and spinosum layers together.

ymptoms

The disease presents with the widespread formation of fluid filled blisters that are thin walled and easily ruptured. Ritter's Disease of the Newborn is the most severe form of SSSS with similar signs and symptoms.

References


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См. также в других словарях:

  • Staphylococcal Scalded Skin Syndrome — Klassifikation nach ICD 10 L00 Staphylococcal scalded skin syndrome (SSS Syndrom) Dermatitis exfoliativa neonatorum (Ritter von Rittershain) Pemphigus acutus neonatorum Staphylogenes Lyell Syndrom …   Deutsch Wikipedia

  • Staphylococcal scalded skin syndrome — Klassifikation nach ICD 10 L00 Staphylococcal scalded skin syndrome (SSS Syndrom) Dermatitis exfoliativa neonatorum (Ritter von Rittershain) Pemphigus acutus neonatorum Staphylogenes Lyell Syndrom …   Deutsch Wikipedia

  • Staphylococcal scalded skin syndrome — An infection of the skin with group II Staphylococcus aurea bacteria. The bacteria release toxins, causing inflamed, scaling skin that looks as though it has been burned. It is more common in children than in adults, but is more likely to cause… …   Medical dictionary

  • staphylococcal scalded skin syndrome — (Lyell s disease, Ritter s disease) a potentially serious condition of young infants in which the skin becomes reddened and tender and then peels off, giving the appearance of a scald. The area of skin loss may be quite extensive. The underlying… …   Medical dictionary

  • staphylococcal scalded skin syndrome — Lyell s disease; = Ritter s disease a potentially serious condition of young infants in which the skin becomes reddened and tender and then peels off, giving the appearance of a scald. The area of skin loss may be quite extensive. The underlying… …   The new mediacal dictionary

  • staphylococcal scalded skin syndrome — (SSSS) A disease caused by staphylococci that produce an exfoliative toxin. The skin becomes red (erythema) and sheets of epidermis may separate from the underlying tissue …   Dictionary of microbiology

  • Болезнь Риттера (Staphylococcal Scalded Skin Syndrome, Ritter 'S Disease) — токсический некроз эпидермиса; развивающееся у младенцев заболевание, вызываемое бактериями рода Staphylococcus и характеризующееся покраснением и расслоением кожи, появлением крупных сливающихся друг с другом пузырей, напоминающих пузыри от… …   Медицинские термины

  • Scalded skin syndrome — A potentially serious side effect of infection with the Staph (Staphylococcus) bacteria that produces a specific protein which loosens the "cement" holding the various layers of the skin together. This allows blister formation and… …   Medical dictionary

  • scalded-skin syndrome — scald·ed skin syndrome skȯld əd n TOXIC EPIDERMAL NECROLYSIS see STAPHYLOCOCCAL SCALDED SKIN SYNDROME …   Medical dictionary

  • Staphylococcal infection — Classification and external resources SEM micrograph of S. aureus colonies; note the grape like clustering common to Staphylococcus species. MeSH …   Wikipedia


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