DCI may be an abbreviation for:
- D-chiro-inositol, an isomer of inositol
- Data, Context, and Interaction, an architectural pattern in computer software development
- Direct Count & Intersect, an algorithm for discovering frequent sets in large databases 
- Digitally Controlled Impedance, Impedance control function in FPGA.
- Display Control Interface, a standard developed by Microsoft and Intel using code from San Francisco Canyon Company for device drivers that control computer graphics cards
- Distributed Computing Infrastructure, a term used in Grid computing referring to the combination of distributed computer resources
- Ductile cast iron, another name of Ductile iron,a more flexible type of cast iron
- Dynamic Content Identification, a Technology that was invented by Clepsta Technologies for SafeLook application, a parental content filtering.
- Défense Conseil International, a French company that provides technical assistance to customers of the French arms industry
- Digital Cinema Initiatives, a joint venture between the major Hollywood studios to establish a specification for a standard digital cinema architecture
- Dredging Corporation of India Limited, an Indian public sector company
- Discovery Communications, an American global media and entertainment company
- Dynamic Cassette International, a Boston, Lincolnshire, UK company that produces products under the Jet Tec brand name
- DCI Cheese Company
- DCI, Inc., formerly known as Dairy Craft, an American firm specializing in stainless steel tank fabrication for pharmaceutical, food production, and chemical storage businesses.
- DCI (Wizards of the Coast) (formerly known as Duelists' Convocation International), the organization that sanctions official tournaments of Wizards of the Coast games, most notably Magic: The Gathering
- Defence for Children International, an independent non-governmental organisation that operates globally to promote and protect children’s rights
- Dental Council of India, an organisation which regulates dental education in India
- Dialysis Clinic, Inc, a nonprofit medical organization headquartered in Nashville, Tennessee
- Drum Corps International, the nonprofit organization governing modern junior drum and bugle corps
- DCI Global Partnerships, the community and work associated with DCI Trust—a UK charity committed to mobilising Christian leaders, providing micro-loans for the economically poor, networking a global Christian constituency and giving to bless the poor of the earth.
- Development Cooperation Instrument
- Director of Central Intelligence, the former title of the head of the U.S. Intelligence Community and Central Intelligence Agency
- Detective Chief Inspector, a police rank in the United Kingdom
- Decompression illness, a medical condition brought on by rapid decompression
- Doctor of Creative Industries, a postgraduate qualification awarded by Queensland University of Technology
- Defence Capabilities Initiative, a 1999 NATO plan to ensure the effectiveness of future multinational operations in the present and foreseeable security environment with a special focus on improving interoperability among Alliance forces.
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