John Carew Eccles


John Carew Eccles

Infobox_Scientist
name = Sir John Eccles


image_width = 150px
caption = John Eccles, shown here at his lab bench
birth_date = birth date|1903|1|27|mf=y
birth_place = Melbourne, Australia
death_date = death date and age|1997|5|2|1903|1|27
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residence =
citizenship =
ethnicity =
nationality = Australian
field = Neuroscience
work_institution =
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prizes = Nobel Prize in Physiology or Medicine (1963)
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Sir John Carew Eccles, AC FRS FRACP FRSNZ FAAS (January 27, 1903 – May 2, 1997) was an Australian neurophysiologist who won the 1963 Nobel Prize in Physiology or Medicine for his work on the synapse. He shared the prize together with Andrew Fielding Huxley and Alan Lloyd Hodgkin.

Biography

Eccles was born in Melbourne, Australia. He attended Melbourne High School and graduated from Melbourne University in 1925. He was awarded a Rhodes Scholarship to study under Charles Scott Sherrington at Oxford University, where he received his Doctor of Philosophy in 1929.

In 1937 Eccles returned to Australia, where he worked on military research during World War II. After the war, he became a professor at the University of Otago in New Zealand. From 1952 to 1962 he worked as a professor at the Australian National University. He won the Australian of the Year Award in 1963, the same year he won the Nobel Prize.

In 1966 he moved to the United States to work at the Institute for Biomedical Research in Chicago. Unhappy with the working conditions there, he left to become a professor at the University at Buffalo from 1968 until he retired in 1975. After retirement, he moved to Switzerland and wrote on the mind-body problem. He died in 1997 in Locarno, Switzerland.

Eccles was a devout theist and a sometime Roman Catholic, and is regarded by many Christians as an exemplar of the successful melding of a life of science with one of faith. A [http://muse.jhu.edu/journals/perspectives_in_biology_and_medicine/v044/44.2karczmar.pdf biography] states that, "although not always a practicing Catholic, Eccles was a theist and a spiritual person, and he believed 'that there is a Divine Providence operating over and above the materialistic happenings of biological evolution'..."

Research

In the early 1950s, Eccles and his colleagues performed the research that would win Eccles the Nobel Prize. To study synapses in the peripheral nervous system, Eccles and colleagues used the stretch reflex as a model. This reflex is easily studied because it consists of only two neurons: a sensory neuron (the muscle spindle fiber) and the motor neuron. The sensory neuron synapses onto the motor neuron in the spinal cord. When Eccles passed a current into the sensory neuron in the quadriceps, the motor neuron innervating the quadriceps produced a small excitatory postsynaptic potential (EPSP). When he passed the same current through the hamstring, the opposing muscle to the quadriceps, he saw an inhibitory postsynaptic potential (IPSP) in the quadriceps motor neuron. Although a single EPSP was not enough to fire an action potential in the motor neuron, the sum of several EPSPs from multiple sensory neurons synapsing onto the motor neuron could cause the motor neuron to fire, thus contracting the quadriceps. On the other hand, IPSPs could subtract from this sum of EPSPs, preventing the motor neuron from firing.

Apart from these seminal experiments, Eccles was key to a number of important developments in neuroscience. Until around 1949, Eccles believed that synaptic transmission was primarily electrical rather than chemical. Although he was wrong in this hypothesis, his arguments led himself and others to perform some of the experiments which proved chemical synaptic transmission. Bernard Katz and Eccles worked together on some of the experiments which elucidated the role of acetylcholine as a neurotransmitter.

Bibliography

* 1932, "Reflex Activity of the Spinal Cord".
* 1953, "The neurophysiological basic of the mind: The principles of neurophysiology", Oxford: Clarendon.
* 1957, "The Physiology of Nerve Cells".
* 1964, "The Physiology of Synapses".
* 1965, "The brain and the unity of conscious experience", London: Cambridge University Press.
* 1969, "The Inhibitory Pathways of the Central Nervous System".
* 1970, "Facing reality: Philosophical Adventures by a Brain Scientist", Berlin: Springer.
* 1973, "The Understanding of the Brain".
* 1977, "The Self and Its Brain", with Karl Popper, Berlin: Springer.
* 1979, "The human mystery", Berlin: Springer.
* 1980, "The Human Psyche".
* 1984, "The Wonder of Being Human - Our Brain & Our Mind", with Daniel N. Robinson, New York, Free Press.
* 1985, "Mind and Brain: The Many-Faceted Problems", (Editor), New York : Paragon House.
* 1989, "Evolution Of The Brain : Creation Of The Self".
* 1994, "How the Self Controls Its Brain".

tyles

* Mr John Eccles (1903-1929)
* Dr John Eccles (1929-1944)
* Prof. John Eccles (1944-1958)
* Sir John Eccles (1958-1997)

External links

* [http://nobelprize.org/medicine/laureates/1963/eccles-bio.html Sir John Eccles Biography] . Nobel Foundation.
* Pratt, D.: [http://www.theosophy-nw.org/theosnw/science/prat-bra.htm "John Eccles on Mind and Brain"] . A theosophical view.
* Sabbatini, R.M.E.: [http://www.cerebromente.org.br/n17/history/neurons5_i.htm Neurons and synapses. The history of its discovery IV. Chemical transmission] . "Brain & Mind", 2004.


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  • John Carew Eccles — Sir John Carew Eccles AC (* 27. Januar 1903 in Melbourne; † 2. Mai 1997 in Locarno) war ein australischer Physiologe und Nobelpreisträger. Mit seinen Forschungen zur Reizweiterleitung von Nervenzellen trug er entscheidend dazu bei, die Vorgänge… …   Deutsch Wikipedia

  • John Carew Eccles — El psiquíatra de Bohemia Cyril Höschl y Sir John Carew Eccles (1993). Sir John Carew Eccles ( * 27 de enero de 1903; Northcote, Victoria, Australia 2 de mayo de 1997, Locarno, Suiza) fue un neurofisiólogo australiano. Estudió medicina en la… …   Wikipedia Español

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  • Medizinnobelpreis 1963: John Carew Eccles — Alan Lloyd Hodgkin — Andrew Fielding Huxley —   Die drei Physiologen wurden gemeinsam für ihre Entdeckungen bezüglich der ionischen Mechanismen, die bei Erregung und Hemmung in peripheren und zentralen Bereichen der Nervenzellenmembran eine Rolle spielen, ausgezeichnet.    Biografien   Sir… …   Universal-Lexikon

  • Sir John Carew Eccles — noun Australian physiologist noted for his research on the conduction of impulses by nerve cells (1903 1997) • Syn: ↑Eccles, ↑John Eccles • Instance Hypernyms: ↑physiologist …   Useful english dictionary

  • John C. Eccles — Sir John Carew Eccles (* 27. Januar 1903 in Melbourne; † 2. Mai 1997 in Locarno) war ein australischer Physiologe und Nobelpreisträger. Mit seinen Forschungen zur Reizweiterleitung von Nervenzellen trug er entscheidend dazu bei, die Vorgänge im… …   Deutsch Wikipedia

  • John C Eccles — Sir John Carew Eccles (* 27. Januar 1903 in Melbourne; † 2. Mai 1997 in Locarno) war ein australischer Physiologe und Nobelpreisträger. Mit seinen Forschungen zur Reizweiterleitung von Nervenzellen trug er entscheidend dazu bei, die Vorgänge im… …   Deutsch Wikipedia

  • John Carew (disambiguation) — John Carew may refer to:*John Carew (b. 1979), Norwegian footballer who plays for Aston Villa F.C. of the Premier League *John Carew (Canadian politician) (b. 1862), lumber merchant and politician in Ontario, Canada *John Carew (regicide) (1622… …   Wikipedia

  • ECCLES John Carew — (1903 1997) (retrato) [véase http://www.iqb.es/diccio/e/ec.htm#eccles]: fisiólogo australiano, coganador con Alan Lloyd Hodgkin y Andrew Fielding Huxley del premio Nobel de medicina y fisiología en 1963 por sus descubrimientos acerca de los… …   Diccionario médico

  • Eccles,Sir John Carew — Ec·cles (ĕkʹəlz), Sir John Carew. 1903 1997. Australian physiologist. He shared a 1963 Nobel Prize for research on nerve cells. * * * …   Universalium


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