Caveolin


Caveolin

protein
Name = Caveolin 1, caveolae protein, 22kDa
caption =


width =
HGNCid = 1527
Symbol = CAV1
AltSymbols = CAV
EntrezGene = 857
OMIM = 601047
RefSeq = NM_001753
UniProt = Q03135
PDB =
ECnumber =
Chromosome = 7
Arm = q
Band = 31
LocusSupplementaryData =
protein
Name = Caveolin 2
caption =


width =
HGNCid = 1528
Symbol = CAV2
AltSymbols =
EntrezGene = 858
OMIM = 601048
RefSeq = NM_001233
UniProt = P51636
PDB =
ECnumber =
Chromosome = 7
Arm = q
Band = 31
LocusSupplementaryData =
protein
Name = Caveolin 3
caption =


width =
HGNCid = 1529
Symbol = CAV3
AltSymbols =
EntrezGene = 859
OMIM = 601253
RefSeq = NM_001234
UniProt = P56539
PDB =
ECnumber =
Chromosome = 3
Arm = p
Band = 25
LocusSupplementaryData =

Caveolins are a family of proteins that are involved in receptor independent endocytosis. The caveolin gene family has three members in vertebrates: CAV1, CAV2, and CAV3, coding for the proteins caveolin-1, caveolin-2 and caveolin-3, respectively. All three members are membrane proteins with similar structure. Caveolin forms oligomers and associates with cholesterol and sphingolipids in certain areas of the cell membrane, leading to the formation of caveolae.

Structure and expression

The caveolins are similar in structure. They all form hairpin loops that are inserted into the cell membrane. Both the C-terminus and the N-terminus face the cytoplasmic side of the membrane. There are two isoforms of caveolin-1: caveolin-1α and caveolin-1β, the latter lacking a part of the N-terminus.

Caveolins are found in the majority of adherent, mammalian cells.
* Caveolin-1 is most prominently expressed in endothelial, fibrous and adipose tissue.
* The expression pattern of caveolin-2 is similar to that of caveolin-1; it seems to be co-expressed with caveolin-1.
* The expression of caveolin-3 is restricted to striated and smooth muscle.

Function

The functions of caveolins are still under intensive investigation. They are best known for their role in the formation of 50 nanometer-sized invaginations of the plasma membrane, called caveolae. Oligomers of caveolin form the coat of these domains. Cells that lack caveolins also lack caveolae. Many functions are ascribed to these domains, ranging from endocytosis and transcytosis to signal transduction.

Caveolin-1 has also been shown to play a role in the integrin signaling. The tyrosine phosphorylated form of caveolin-1 colocalizes with focal adhesions, suggesting a role for caveolin-1 in migration. Indeed, downregulation of caveolin-1 leads to less efficient migration in vitro.

Genetically engineered mice that lack caveolin-1 and caveolin-2 are viable and fertile, showing that neither the caveolins, nor caveolae are essential in embryonic development or reproduction of these animals. However, knock-out animals do develop abnormal, hypertrophic lungs and cardiac myopathy, leading to a reduction in life span. Mice lacking caveolins also suffer from impaired angiogenic responses as well as abnormal responses to vasoconstrictive stimuli. In zebrafish, lack of caveolins leads to embryonic lethality, suggesting that higher vertebrates (as exemplified by mice) have developed compensation or redundancy for the functions of caveolins.

Role in disease

Cancer

Caveolins have a paradoxical role in the development of this disease. They have been implicated in both tumor suppression and oncogenesis. High expression of caveolins leads to inhibition of cancer-related pathways, such as growth factor signaling pathways. However, certain cancer cells that express caveolins have been shown to be more aggressive and metastatic, because of a potential for anchorage-independent growth.

Cardiovascular diseases

Caveolins are thought to play an important role during the development of atherosclerosis.Furthermore, caveolin-3 has been associated with Long QT syndrome.

Muscular dystrophy

Caveolin-3 has been implicated in the development of certain muscular dystrophies.

External links

* [http://macromoleculeinsights.com/caveolin.php The Caveolin Protein]
*
* [http://www.dmd.nl/cav3_home.html Caveolin-3 page]

References

*cite journal
title=The Caveolin proteins
author=Terence M Williams
coauthors=Michael P Lisanti
journal=Genome Biol.
year=2004
volume=5
issue=3
pages=214
pmid=15003112
doi=10.1186/gb-2004-5-3-214


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Look at other dictionaries:

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  • CAV2 — Caveolin 2, also known as CAV2, is a human gene.cite web | title = Entrez Gene: CAV2 caveolin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=858| accessdate = ] The protein encoded by this gene is a… …   Wikipedia

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