BU-48

drugbox

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IUPAC_name = N-Cyclopropylmethyl- [7α,8α,2',3'] -cyclohexano-1' [S] -hydroxy-6,14-endo-ethenotetrahydronororipavine
PubChem = 10003114
C = 27 | H = 33 | N = 1 | O = 4
molecular_weight = 435.554 g/mol
smiles = C8CC8CN5CCC26C1Oc7c2c(ccc7O)CC5C46C=CC1(OC)C3C4CCCC3O
CAS_number =
legal_status =

BU-48 is a drug which is used in scientific research. It is from the oripavine family, related to better known drugs such as etorphine and buprenorphine.

Unlike most drugs from this family, BU-48 has only weak analgesic effects and acts primarily as a δ-opioid agonist. Its main effects are to produce convulsions, [Broom DC, Guo L, Coop A, Husbands S, Lewis JW, Woods JH, Traynor JR. BU48: A novel buprenorphine analogue that exhibits delta-opioid mediated convulsions but not delta-opioid mediated antinociception in mice. "Journal of Pharmacology and Experimental Therapeutics" 2000 Sep; 294(3): 1195–1200. PMID 10945877] but it may also have antidepressant effects. [Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Behavioral effects of delta-opioid receptor agonists: potential antidepressants? "Japanese Journal of Pharmacology". 2002 Sep;90(1):1-6. PMID 12396021]

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