Pyrazolopyrimidine

Pyrazolopyrimidine

The Pyrazolopyrimidines are a class of sedative and anxiolytic drugs related (in terms of their effect) to benzodiazepines.

Most of the drugs from this class marketed to date are intended to induce sleep, and are prescribed for people suffering insomnia, however some newer compounds produce anxiolytic effects with relatively little sedation, and are being developed for use as non-sedating anti-anxiety drugs.

They include:

* Zaleplon - hypnotic (trade name Sonata)
* Indiplon - hypnotic
* Ocinaplon - anxiolytic

As they are not chemically related to the benzodiazepines despite their similar effect, such drugs—as well as the imidazopyridines and cyclopyrrones—are sometimes grouped together and referred to as "nonbenzodiazepines".

Insecticide

A related use is in pyrazolopyrimidine organothiophosphate insecticides.

tructure

The molecules are typified by the linked six sided (benzene) and sometimes five sided rings (methylpyrazol).


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  • pyrazolopyrimidine — noun Any of a class of sedative and anxiolytic drugs with similar effects to benzodiazepines, their molecules typified by the linked six sided pyrimidine ring and five sided pyrazole ring …   Wiktionary

  • pyrazolopyrimidine — pyra·zo·lo·py·rim·i·dine (pir″ə zo lo pi rimґĭ dēn) any in a class of sedative hypnotics that have effects similar to those of the benzodeazepines …   Medical dictionary

  • Ocinaplon — Systematic (IUPAC) name pyridin 2 yl (7 pyridin 4 ylpyrazolo[1,5 a]pyrimidin 3 yl)methanone Clinical data Pregnancy cat.  …   Wikipedia

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  • Imidazopyridine — The imidazopyridines are a class of sedative drugs related (in terms of their effect) to benzodiazepines. They include:* Zolpidem (Ambien) * Alpidem * Saripidem * NecopidemAs they are not chemically related to the benzodiazepines despite their… …   Wikipedia

  • Zaleplon — Drugbox IUPAC name = N (3 (3 cyanopyrazolo [1,5 a ] pyrimidin 7 yl)phenyl) N ethylacetamide width=140 CAS number= 151319 34 5 ATC prefix=N05 ATC suffix=CF03 ATC supplemental= PubChem=5719 DrugBank=APRD00411 C=17 | H=15 | N=5 | O=1 molecular… …   Wikipedia

  • Tracazolate — drugbox IUPAC name = ethyl 4 butylamino 1 ethyl 6 methylpyrazolo [4,5 e] pyridine 5 carboxylate CAS number = 41094 88 6 ATC prefix = ATC suffix = PubChem = 5522 DrugBank = C=16|H=24|N=4|O=2 molecular weight = 304.387 g/mol bioavailability =… …   Wikipedia

  • Zaleplon — Strukturformel Allgemeines Freiname Zaleplon …   Deutsch Wikipedia

  • Sildénafil — Général Nom IUPAC …   Wikipédia en Français

  • Zaleplon — Général Nom IUPAC N (3 (3 cyanopyrazolo[1,5 a] pyrimidin 7 yl)phenyl) N ethylacetamide …   Wikipédia en Français

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