Carboxytherapy is a non-surgical cosmetic medicine treatment. Carboxytherapy employs injections to infuse gaseous carbon dioxide below the skin into the subcutaneous tissue through a tiny needle. It claims to kill fat cells, stimulate blood flow, improve the skin's elasticity and reduce the appearance of cellulite.


Carboxytherapy is a mesotherapy like non-surgical procedure used to infuse CO2 gas below the skin (sub-cutaneous or intradermic) through a thin 30G mesotherapy needle. Treatments are quick, comfortable, effective with no down time. CO2 gas stimulates blood flow with several consequences: skin elasticity improvement, peau d'orange cellulite reduction, localized fat reduction and collagen production stimulation. Carboxytherapy is a good alternative to liposuction for person who are not willing to go through anesthesia and surgical operations.

Carboxytherapy works in two different ways: it first fragilizes fat cells with a pressure traumatism, then, in second, CO2 leads to flood vassels dilation in the area where the gas is injected. This reaction to carbon dioxide injection gives a better oxygenation of skin layers with increased lipolysis capabilities (Bohr Effet). The end result is fewer fat cells and skin tightening.

Carboxytherapy has been used for over 70 years in Europe where it was discovered (France, Royat). The procedure was widely used to treat ischemic vascular diseases because of the vasodilation properties of CO2.

Carboxytherapy procedures

Cellulite reductionLocalized fat & weight reduction with or without liposuctionLiposuction complementary solution to clear pending irregularities. Arterial diseases associated with diabetesSkin ulcers Some erection problems deue to vascular disordersStretck marksAcné scars & Skin laxity (arms, chest, ...)Wrinkles redution


Carbon dioxide therapy: effects on skin irregularity and its use as a complement to liposuction.Brandi C, D'Aniello C, Grimaldi L, Caiazzo E, Stanghellini E. []

Carbon dioxide therapy in the treatment of localized adiposities: clinical study and histopathological correlations. [Brandi C, D'Aniello C, Grimaldi L, Bosi B, Dei I, Lattarulo P, Alessandrini C. []


Carboxyworld []

ee also

*Injection lipolysis


*cite journal |last=Campos |first=Valeria |authorlink= |coauthors=Leila Bloch, Tatiane Cordeiro |year=2007 |month=February |title=Carboxytherapy for gynoid lipodystrophy treatment: The Brazilian experience |journal=Journal of the American Academy of Dermatology |volume=56 |issue=2 |pages=AB196 |id= |url= |accessdate= 2008-04-26 |quote=

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4. Jordan F, Faucon G. Diffusibilité de l’anhydride carbonique, pH régional et régulation vasculaire périphérique. CR Soc Biol 1958;152:706-9

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6. Pochon P. Observation par effet Doppler des effets de la cure thermale de Royat. Press Therm Climat 1979;4.

7. Komoto Y,Nakao T, Sunakawa M et a. Elevation of tissue PO2 with improvement of tissue perfusion by tropically applied CO2. Adv Exp Med Biol 1985;222:637-45.

8. Schnizer W, Erdl R, Schöps et al. The effects of external CO2 application in human skin microcirculation investigated by laser Doppler flux flowmeter. Int j Microcirc Clin Exp 1985;38:343-50.

9. Bedu M, Cheynel J, Gascard JP, Coudert J. Transcutaneous CO2 diffusion : comparison between CO2 spa water and dry gas in Royat thermal spa. In : Strano A, Novo S, eds. Advances in Vascular pathology 1989:1109-14

10. Coudert J, Bedu M, Cheynel J, Savin E, Martineaud JP. Effets vasculaires de la diffusion transcutanée du dioxyde de carbone d’origine thermale. Press Therm Climat 1991;128(3):110-4.

11. Lecomte J, Namur M, Juchmes J. Propriétés physiologiques du bain carbo-gazeux de Spa, bain local et CO2 sec. Rev Med Liège 1975;30:657-65.

12. Delahaye R, Cheynel, Savin E, Verny C, Vidil J. Place de la crénothérapie dans la prise en charge et la rééducation des artériopathes. In : Herisson Ch, Jambon Ch, Casillas JM, eds. Pathologie vasculaire des membres. Paris : Masson, 1993:115-28.

13. Hartmann Bernd R, Bassenge FE, Hartmann M. Effects of serial percutaneous application of carbon dioxide in intermittent claudication : results of a controlled trial. Angiology 1997;48(11):957-63.

14. Savin E, Bailliart O, Bonnin P et al. Vasomotor effects of transcutaneous CO2 in stage II peripheral occlusivearterial disease. Angiology 1995;46:785-91

15. Ambrosi C, Delanoe G, Action thérapeutique du CO2 naturel injecté sous la peau dans les artériopathies des membres. Etude expérimentale. Ann Cardiol Angeiol 1976;25(2):93-8.

16. Fabry-Delaigue R, Pochon P, Trolèse JF, Duchène-Marullaz P. Variations du pérmètre de marche et des index de pression systolique avant et après épreuve de marche mesurée à un an d’intervalle chez 140 artériopathes traités à Royat. Cahiers d’Artériologie 1985;11:72-82.

17. Fabry R, Dubost JJ, Schmidt J, Body J, Schaff G, Baguet JC. Le traitement thermal des maladies artérielles : un placebo coûteux ou une thérapeutique à part entière ? Thérapie 1995;50:113-22.

18. Fabry R, Monnet P, Normand B, Lusson JR, Baguet JC. Epidemiological follow-up of a cohort of 600 patients with stage II atheroclerosis obliterans of the lower limbs. Prospective study, 1981-1996. Effect of medical treatment. Int Epidemiol (sous presse).

19. Motz B, Bassenge E, Hartmann B. Effects of CO2 therapy in Raynaud’s syndrom. Results of a controlled trial. Br j Dermatol 1998 .

20. Fabry R, Monnet P, Schmidt J, Schaff G. Chronothermobiology computerized in the Raynaud Phenomenon (RP) : Diagnostic interest and evaluation of a therapy. J Vasc Res 1998;35(suppl2):52.

20. Cahiers d’Artériologie de Royat. Tomes 18, 20 et 22

21. Hartmann B.- Result of the Consensus-Finding Conference on Carbon Dioxide Balneotherapy- Phys.Med.Baln.Med.Klim.-19 (1990) -11-12.

22. Schmidt J., Monnet P., Normand B., Fabry R.-Microcirculatory and clinical effects of serial percutaneous application of cabon dioxide in primary and secondary Raynaud’s phenomenon- VASA-2005;34:93-100.

23. Aesthetic Plast Surg. 2001 May-Jun;25(3):170-4. Carbon dioxide therapy in the treatment of localized adiposities: clinical study and histopathological correlations. Brandi C, D'Aniello C, Grimaldi L, Bosi B, Dei I, Lattarulo P, Alessandrini C. Unità Operativa di Chirurgia Plastica, Università digli Studi di Siena, Policlinico Le Scotte, Italy

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