PDF (gene)

Peptide deformylase (mitochondrial)
Identifiers
Symbols	PDF;
External IDs	HomoloGene: 69354 GeneCards: PDF Gene
EC number	3.5.1.88
Gene Ontology Molecular function • iron ion binding • hydrolase activity • peptide deformylase activity • metal ion binding Cellular component • mitochondrion Biological process • translation • positive regulation of cell proliferation • peptidyl-methionine modification • N-terminal protein amino acid modification
Orthologs
Species	Human	Mouse
Entrez	64146	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	NM_022341	n/a
RefSeq (protein)	NP_071736	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a

Peptide deformylase, mitochondrial is an enzyme that in humans is encoded by the PDF gene.^[1][2][3]

References

1. ^ Giglione C, Serero A, Pierre M, Boisson B, Meinnel T (Nov 2000). "Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms". EMBO J 19 (21): 5916–29. doi:10.1093/emboj/19.21.5916. PMC 305796. PMID 11060042. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305796. 
2. ^ Lee MD, She Y, Soskis MJ, Borella CP, Gardner JR, Hayes PA, Dy BM, Heaney ML, Philips MR, Bornmann WG, Sirotnak FM, Scheinberg DA (Oct 2004). "Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics". J Clin Invest 114 (8): 1107–16. doi:10.1172/JCI22269. PMC 522256. PMID 15489958. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=522256. 
3. ^ "Entrez Gene: PDF peptide deformylase (mitochondrial)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64146. 

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Lee MD, Antczak C, Li Y, et al. (2004). "A new human peptide deformylase inhibitable by actinonin.". Biochem. Biophys. Res. Commun. 312 (2): 309–15. doi:10.1016/j.bbrc.2003.10.123. PMID 14637138. 
• Serero A, Giglione C, Sardini A, et al. (2004). "An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway.". J. Biol. Chem. 278 (52): 52953–63. doi:10.1074/jbc.M309770200. PMID 14532271. 
• Nguyen KT, Hu X, Colton C, et al. (2003). "Characterization of a human peptide deformylase: implications for antibacterial drug design.". Biochemistry 42 (33): 9952–8. doi:10.1021/bi0346446. PMID 12924944. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=378590. 

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