SFRP5


SFRP5

Secreted frizzled-related protein 5, also known as SFRP5, is a human gene.cite web | title = Entrez Gene: SFRP5 secreted frizzled-related protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6425| accessdate = ]

PBB_Summary
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summary_text = Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas.cite web | title = Entrez Gene: SFRP5 secreted frizzled-related protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6425| accessdate = ]

References

Further reading

*cite journal | author=Veeck J, Geisler C, Noetzel E, "et al." |title=Epigenetic inactivation of the Secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. |journal=Carcinogenesis. |volume=29 |issue= 5 |pages= 991-998 |year= 2008 |pmid= 18356147 |doi= 10.1093/carcin/bgn076 PBB_Further_reading
citations =
*cite journal | author=Urakami S, Shiina H, Enokida H, "et al." |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109-16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chang JT, Esumi N, Moore K, "et al." |title=Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 575-83 |year= 1999 |pmid= 10072424 |doi=
*cite journal | author=Hu E, Zhu Y, Fredrickson T, "et al." |title=Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 2 |pages= 287-93 |year= 1998 |pmid= 9642118 |doi= 10.1006/bbrc.1998.8784
*cite journal | author=Melkonyan HS, Chang WC, Shapiro JP, "et al." |title=SARPs: a family of secreted apoptosis-related proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 25 |pages= 13636-41 |year= 1998 |pmid= 9391078 |doi=
*cite journal | author=Rattner A, Hsieh JC, Smallwood PM, "et al." |title=A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 7 |pages= 2859-63 |year= 1997 |pmid= 9096311 |doi=

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  • Secreted frizzled-related protein 1 — The Secreted frizzled related protein (SFRP) family consists of five secreted glycoproteins in humans ( 300 amino acids in length) that act as extracellular signaling ligands. Each SFRP contains a cysteine rich domain (CRD) that shares 30 50%… …   Wikipedia


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