PANK1


PANK1
Pantothenate kinase 1

PDB rendering based on 2i7n.
Identifiers
Symbols PANK1; MGC24596; PANK
External IDs OMIM606160 MGI1922985 HomoloGene56979 GeneCards: PANK1 Gene
EC number 2.7.1.33
Orthologs
Species Human Mouse
Entrez 53354 75735
Ensembl ENSG00000152782 ENSMUSG00000033610
UniProt Q8TE04 Q543J7
RefSeq (mRNA) NM_138316.3 XM_973598
RefSeq (protein) NP_612189.2 XP_978692
Location (UCSC) Chr 10:
91.34 – 91.41 Mb
Chr 19:
34.89 – 34.95 Mb
PubMed search [1] [2]

Pantothenate kinase 1 is an enzyme that in humans is encoded by the PANK1 gene.[1]

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, have been identified.[1]

References

Further reading


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  • Pantothenate kinase — (PanK; CoaA) is the first enzyme in the Coenzyme A biosynthetic pathway. It phophorylates pantothenate (vitamin B5) to form 4 phosphopantothenate. Types Three distinct types of PanK has been identified PanK I (found in bacteria), PanK II (mainly… …   Wikipedia

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