Cornification is the process of forming an epidermal barrier in stratified squamous epithelial tissue.

At cellular level cornification is characterised by

* production of keratin
* production of small proline-rich (SPRR) proteins and transglutaminase which eventually form a cornified cell envelope beneath the plasma membrane
* terminal differentiation
* loss of nuclei and organelles, in the final stages of cornification metabolism ceases and the cells are completely filled by keratin

Sources: Harvcoltxt |Matsuda |Osaki |Hashii |Koshiba |2007 and Harvcoltxt |Steinert |Kartasova |Marekov |1998 .

ee also

* Keratin and Cornification


* cite journal |author=Matsuda Y, Osaki T, Hashii T, Koshiba T, Kawabata S |title=A cysteine-rich protein from an arthropod stabilizes clotting mesh and immobilizes bacteria at injury sites |journal=J. Biol. Chem. |volume=282 |issue=46 |pages=33545–52 |year=2007 |month=November |pmid=17855345 |doi=10.1074/jbc.M705854200 |url=
* cite journal |author=Steinert PM, Kartasova T, Marekov LN |title=Biochemical evidence that small proline-rich proteins and trichohyalin function in epithelia by modulation of the biomechanical properties of their cornified cell envelopes |journal=J. Biol. Chem. |volume=273 |issue=19 |pages=11758–69 |year=1998 |month=May |pmid=9565599 |doi= |url=

Wikimedia Foundation. 2010.