Macroglossia


Macroglossia
Macroglossia
Classification and external resources
ICD-10 Q38.2
ICD-9 529.8
OMIM 153630
DiseasesDB 7689
eMedicine ent/746
MeSH D008260

Macroglossia is the medical term for unusual enlargement (hypertrophy) of the tongue. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping.

Contents

Causes

Amyloid Disorders

Amyloidosis is an accumulation of insoluble proteins in tissues that impedes normal function.[1]

  • 1. Primary amyloidosis
  • 2. Myeloma associated amyloidosis[2]
  • 3. Lubarsch Pick syndrome [3]
  • 4. Immunoglobulinemic amyloidosis

Hypothyroid Macroglossia

Macroglossia is also a clinical feature in Hypothyroid disorders which include

Overgrowth Disorders

Chromosomal disorders

1. Triploid Syndrome
2. Chromosome 4,trisomy 4p

3. Trisomy 21 (Downs Syndrome)

Other Miscellaneous

1. Mucopolysaccharidosis[10]
2. MANNOSIDOSIS, ALPHA B, LYSOSOMAL[11]
3. Glycogen storage disease type 2, or Pompe's disease.[12]
4. Fucosidosis

Apparent macroglossia can also occur in Down syndrome.[13]

References

External links