Macroglossia

Macroglossia
Classification and external resources
ICD-10	Q38.2
ICD-9	529.8
OMIM	153630
DiseasesDB	7689
eMedicine	ent/746
MeSH	D008260

Macroglossia is the medical term for unusual enlargement (hypertrophy) of the tongue. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping.

Causes

Amyloid Disorders

Amyloidosis is an accumulation of insoluble proteins in tissues that impedes normal function.^[1]

• 1. Primary amyloidosis
• 2. Myeloma associated amyloidosis^[2]
• 3. Lubarsch Pick syndrome ^[3]
• 4. Immunoglobulinemic amyloidosis

Hypothyroid Macroglossia

Macroglossia is also a clinical feature in Hypothyroid disorders which include

• 1. congenital hypothyroidism,^[4].
• 2. Young Simpson syndrome,^[5]
• 3. Zadik Barak Levin syndrome,^[6]
• 4. Athyreotic cretinism
• 5. Kocher-Debre-Semelaigne syndrome^[7]

Overgrowth Disorders

• 1. Beckwith-Wiedemann syndrome^[8]
• 2. Simpson-Golabi-Behmel syndrome^[9]
• 3. Acromegaly

Chromosomal disorders

1. Triploid Syndrome
2. Chromosome 4,trisomy 4p

3. Trisomy 21 (Downs Syndrome)

Other Miscellaneous

1. Mucopolysaccharidosis^[10]
2. MANNOSIDOSIS, ALPHA B, LYSOSOMAL^[11]
3. Glycogen storage disease type 2, or Pompe's disease.^[12]
4. Fucosidosis

Apparent macroglossia can also occur in Down syndrome.^[13]

References

1. ^ Merck Manual 17th Ed.
2. ^ http://sciencelinks.jp/j-east/article/200318/000020031803A0392321.php
3. ^ http://en.wikipedia.org/wiki/Ludwig_Pick
4. ^ Grant DB, Smith I, Fuggle PW, Tokar S, Chapple J (January 1992). "Congenital hypothyroidism detected by neonatal screening: relationship between biochemical severity and early clinical features". Arch. Dis. Child. 67 (1): 87–90. doi:10.1136/adc.67.1.87. PMC 1793539. PMID 1739345. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1793539. 
5. ^ http://sciencelinks.jp/j-east/article/200223/000020022302A0895118.php
6. ^ http://en.wikipedia.org/wiki/Zadik_Barak_Levin_syndrome
7. ^ http://www.springerlink.com/content/lh807890491x17h3/
8. ^ http://www.joms.org/article/S0278-2391(00)69867-1/abstract
9. ^ http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=312870
10. ^ http://ghr.nlm.nih.gov/condition=mucopolysaccharidosistypei
11. ^ http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=248500
12. ^ http://moon.ouhsc.edu/kfung/jty1/neurohelp/ZNN0IE23.htm
13. ^ Guimaraes CV, Donnelly LF, Shott SR, Amin RS, Kalra M (October 2008). "Relative rather than absolute macroglossia in patients with Down syndrome: implications for treatment of obstructive sleep apnea". Pediatr Radiol 38 (10): 1062–7. doi:10.1007/s00247-008-0941-7. PMID 18685841. 

External links

• Grand Rounds Site

This medical sign article is a stub. You can help Wikipedia by expanding it.v · Categories: Medical sign stubs Tongue disorders Congenital disorders of digestive system Thyroid disease Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Regional policy of the European Union Fossa (animal) Look at other dictionaries: Macroglossia — Mac ro*glos si*a, n. [NL. See {Macro }, and {Glossa}.] (Med.) Enlargement or hypertrophy of the tongue. [1913 Webster] …   The Collaborative International Dictionary of English Macroglossia — didžialiežuvystė statusas T sritis gyvūnų raida, augimas, ontogenezė, embriologija atitikmenys: lot. Macroglossia ryšiai: platesnis terminas – liežuvio ydos …   Veterinarinės anatomijos, histologijos ir embriologijos terminai Macroglossia — didžialiežuvystė statusas T sritis embriologija atitikmenys: lot. Macroglossia ryšiai: platesnis terminas – liežuvio ydos …   Medicininės histologijos ir embriologijos vardynas macroglossia — ▪ pathology       enlargement of the tongue, due to overdevelopment of the muscle or the accumulation of material within the tongue. Muscular hypertrophy may be congenital, as in Down syndrome, or may develop later in life, as in acromegaly.… …   Universalium macroglossia — noun Enlargement or hypertrophy of the tongue …   Wiktionary macroglossia — Enlargement of the tongue, either developmental in origin or secondary to a neoplasm or vascular hamartoma. SYN: megaloglossia. [macro + G. glossa, tongue] * * * mac·ro·glos·sia .mak rō gläs ē ə, glȯs n pathological and commonly congenital… …   Medical dictionary macroglòssia — ma|cro|glòs|si|a Mot Esdrúixol Nom femení …   Diccionari Català-Català macroglossia — ma·cro·glos·sì·a s.f. TS med. eccessivo sviluppo della lingua {{line}} {{/line}} DATA: 1895. ETIMO: comp. di macro e glossia …   Dizionario italiano macroglossia — pl.f. macroglossie …   Dizionario dei sinonimi e contrari macroglossia — mac·ro·glos·sia …   English syllables 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”