- Laser spray
Laser spray is a new
liquid chromatography/ mass spectrometryinterface. Explosive vaporization and mistformation occur when an aqueous solutioneffusing out from the tip of the stainless steel capillaryis irradiated from the opposite side of the capillary by a 10.6 μm infrared laser. Weak ion signals could be detected when the plume was sampled through the ion sampling orifice. When a high voltage(3–4 kV) was applied to the stainless-steel capillary, strong ion signals appeared. The ion abundances were found to be orders of magnitude greater than those obtained by conventional electrosprayionization in the case of aqueous solutions.
Laser spray is a
hybridof three basic techniques for the generation of gaseous ions from the condensed phase, i.e., energy-sudden activation, nebulization and the action of an electric field. ["Laser spray: electric field-assisted matrix-assisted laser desorption/ionization" Hiraoka, K. J. Mass Spectrom. 2004; 39: 341. ]
Laser spray mass spectrometry can faithfully reflect the solution-phase characteristics of
biomolecules. It has been successfully applied to evaluate the binding affinities of protein- [DNA] .
Laser spray has better ionization efficiency than conventional electrospray
ionization(ESI)  . In particular, the sensitivity became more than one order of magnitude higher in negative ion modes. It was also found that this technique has a potential benefit for the low concentration samples due to condensation effect of the formed droplet by the irradiation of laser.
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