Luteinizing hormone beta polypeptide


Luteinizing hormone beta polypeptide

Luteinizing hormone beta polypeptide, also known as LHB, is a human gene.cite web | title = Entrez Gene: LHB luteinizing hormone beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3972| accessdate = ]

PBB_Summary
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summary_text = This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.cite web | title = Entrez Gene: LHB luteinizing hormone beta polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3972| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sairam MR, Li CH |title=Human pituitary lutropin. Isolation, properties, and the complete amino acid sequence of the beta-subunit. |journal=Biochim. Biophys. Acta |volume=412 |issue= 1 |pages= 70–81 |year= 1976 |pmid= 1191677 |doi=
*cite journal | author=Keutmann HT, Hua QX, Weiss MA |title=Structure of a receptor-binding fragment from human luteinizing hormone beta-subunit determined by [1H] - and [15N] nuclear magnetic resonance spectroscopy. |journal=Mol. Endocrinol. |volume=6 |issue= 6 |pages= 904–13 |year= 1992 |pmid= 1495492 |doi=
*cite journal | author=Weiss J, Axelrod L, Whitcomb RW, "et al." |title=Hypogonadism caused by a single amino acid substitution in the beta subunit of luteinizing hormone. |journal=N. Engl. J. Med. |volume=326 |issue= 3 |pages= 179–83 |year= 1992 |pmid= 1727547 |doi=
*cite journal | author=Weisshaar G, Hiyama J, Renwick AG, Nimtz M |title=NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin. |journal=Eur. J. Biochem. |volume=195 |issue= 1 |pages= 257–68 |year= 1991 |pmid= 1991473 |doi=
*cite journal | author=Jameson JL, Lindell CM, Habener JF |title=Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes. |journal=DNA |volume=5 |issue= 3 |pages= 227–34 |year= 1986 |pmid= 2424697 |doi=
*cite journal | author=Keutmann HT, Charlesworth MC, Mason KA, "et al." |title=A receptor-binding region in human choriogonadotropin/lutropin beta subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 7 |pages= 2038–42 |year= 1987 |pmid= 3470775 |doi=
*cite journal | author=Shome B, Parlow AF |title=The primary structure of the hormone-specific, beta subunit of human pituitary luteinizing hormone (hLH). |journal=J. Clin. Endocrinol. Metab. |volume=36 |issue= 3 |pages= 618–21 |year= 1973 |pmid= 4685398 |doi=
*cite journal | author=Closset J, Hennen G, Lequin RM |title=Human luteinizing hormone. The amino acid sequence of the subunit. |journal=FEBS Lett. |volume=29 |issue= 2 |pages= 97–100 |year= 1973 |pmid= 4719207 |doi=
*cite journal | author=Talmadge K, Vamvakopoulos NC, Fiddes JC |title=Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. |journal=Nature |volume=307 |issue= 5946 |pages= 37–40 |year= 1984 |pmid= 6690982 |doi=
*cite journal | author=Beitins IZ, Axelrod L, Ostrea T, "et al." |title=Hypogonadism in a male with an immunologically active, biologically inactive luteinizing hormone: characterization of the abnormal hormone. |journal=J. Clin. Endocrinol. Metab. |volume=52 |issue= 6 |pages= 1143–9 |year= 1981 |pmid= 6785294 |doi=
*cite journal | author=Berger P, Kranewitter W, Madersbacher S, "et al." |title=Eutopic production of human chorionic gonadotropin beta (hCG beta) and luteinizing hormone beta (hLH beta) in the human testis. |journal=FEBS Lett. |volume=343 |issue= 3 |pages= 229–33 |year= 1994 |pmid= 7513655 |doi=
*cite journal | author=Keutmann HT, Rubin DA |title=A subunit interaction site in human luteinizing hormone: identification by photoaffinity cross-linking. |journal=Endocrinology |volume=132 |issue= 3 |pages= 1305–12 |year= 1993 |pmid= 7679977 |doi=
*cite journal | author=Herrlich A, Kühn B, Grosse R, "et al." |title=Involvement of Gs and Gi proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C. |journal=J. Biol. Chem. |volume=271 |issue= 28 |pages= 16764–72 |year= 1996 |pmid= 8663226 |doi=
*cite journal | author=Muyan M, Furuhashi M, Sugahara T, Boime I |title=The carboxy-terminal region of the beta-subunits of luteinizing hormone and chorionic gonadotropin differentially influence secretion and assembly of the heterodimers. |journal=Mol. Endocrinol. |volume=10 |issue= 12 |pages= 1678–87 |year= 1997 |pmid= 8961276 |doi=
*cite journal | author=Roy AC, Liao WX, Chen Y, "et al." |title=Identification of seven novel mutations in LH beta-subunit gene by SSCP. |journal=Mol. Cell. Biochem. |volume=165 |issue= 2 |pages= 151–3 |year= 1997 |pmid= 8979264 |doi=
*cite journal | author=Liao WX, Roy AC, Chan C, "et al." |title=A new molecular variant of luteinizing hormone associated with female infertility. |journal=Fertil. Steril. |volume=69 |issue= 1 |pages= 102–6 |year= 1998 |pmid= 9457942 |doi=
*cite journal | author=O'Connor JF, Kovalevskaya G, Birken S, "et al." |title=The expression of the urinary forms of human luteinizing hormone beta fragment in various populations as assessed by a specific immunoradiometric assay. |journal=Hum. Reprod. |volume=13 |issue= 4 |pages= 826–35 |year= 1998 |pmid= 9619532 |doi=
*cite journal | author=Takahashi K, Kurioka H, Ozaki T, "et al." |title=Increased prevalence of luteinizing hormone beta-subunit variant in Japanese infertility patients. |journal=Hum. Reprod. |volume=13 |issue= 12 |pages= 3338–44 |year= 1999 |pmid= 9886510 |doi=
*cite journal | author=Elter K, Erel CT, Cine N, "et al." |title=Role of the mutations Trp8 => Arg and Ile15 => Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome. |journal=Fertil. Steril. |volume=71 |issue= 3 |pages= 425–30 |year= 1999 |pmid= 10065776 |doi=
*cite journal | author=Jiang M, Pakarinen P, Zhang FP, "et al." |title=A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence. |journal=Hum. Mol. Genet. |volume=8 |issue= 11 |pages= 2037–46 |year= 1999 |pmid= 10484773 |doi=

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