MAPK11

Mitogen-activated protein kinase 11, also known as MAPK11, is a human gene.cite web | title = Entrez Gene: MAPK11 mitogen-activated protein kinase 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5600| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.cite web | title = Entrez Gene: MAPK11 mitogen-activated protein kinase 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5600| accessdate = ]

ee also

* p38 mitogen-activated protein kinases

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jiang Y, Chen C, Li Z, "et al." |title=Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 17920–6 |year= 1996 |pmid= 8663524 |doi=
*cite journal | author=Kumar S, McDonnell PC, Gum RJ, "et al." |title=Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 533–8 |year= 1997 |pmid= 9207191 |doi= 10.1006/bbrc.1997.6849
*cite journal | author=Goedert M, Cuenda A, Craxton M, "et al." |title=Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. |journal=EMBO J. |volume=16 |issue= 12 |pages= 3563–71 |year= 1997 |pmid= 9218798 |doi= 10.1093/emboj/16.12.3563
*cite journal | author=Stein B, Yang MX, Young DB, "et al." |title=p38-2, a novel mitogen-activated protein kinase with distinct properties. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19509–17 |year= 1997 |pmid= 9235954 |doi=
*cite journal | author=Enslen H, Raingeaud J, Davis RJ |title=Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1741–8 |year= 1998 |pmid= 9430721 |doi=
*cite journal | author=New L, Jiang Y, Zhao M, "et al." |title=PRAK, a novel protein kinase regulated by the p38 MAP kinase. |journal=EMBO J. |volume=17 |issue= 12 |pages= 3372–84 |year= 1998 |pmid= 9628874 |doi= 10.1093/emboj/17.12.3372
*cite journal | author=Deak M, Clifton AD, Lucocq LM, Alessi DR |title=Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. |journal=EMBO J. |volume=17 |issue= 15 |pages= 4426–41 |year= 1998 |pmid= 9687510 |doi= 10.1093/emboj/17.15.4426
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Lee SH, Park J, Che Y, "et al." |title=Constitutive activity and differential localization of p38alpha and p38beta MAPKs in adult mouse brain. |journal=J. Neurosci. Res. |volume=60 |issue= 5 |pages= 623–31 |year= 2000 |pmid= 10820433 |doi=
*cite journal | author=Tanoue T, Yamamoto T, Maeda R, Nishida E |title=A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26629–39 |year= 2001 |pmid= 11359773 |doi= 10.1074/jbc.M101981200
*cite journal | author=Torcia M, De Chiara G, Nencioni L, "et al." |title=Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39027–36 |year= 2001 |pmid= 11495898 |doi= 10.1074/jbc.M102970200
*cite journal | author=Driggers PH, Segars JH, Rubino DM |title=The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 46792–7 |year= 2002 |pmid= 11579095 |doi= 10.1074/jbc.M106927200
*cite journal | author=Ge B, Gram H, Di Padova F, "et al." |title=MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. |journal=Science |volume=295 |issue= 5558 |pages= 1291–4 |year= 2002 |pmid= 11847341 |doi= 10.1126/science.1067289
*cite journal | author=Reunanen N, Li SP, Ahonen M, "et al." |title=Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 32360–8 |year= 2002 |pmid= 12060661 |doi= 10.1074/jbc.M204296200
*cite journal | author=Knebel A, Haydon CE, Morrice N, Cohen P |title=Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. |journal=Biochem. J. |volume=367 |issue= Pt 2 |pages= 525–32 |year= 2002 |pmid= 12171600 |doi= 10.1042/BJ20020916
*cite journal | author=Kinet S, Bernard F, Mongellaz C, "et al." |title=gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes. |journal=Blood |volume=100 |issue= 7 |pages= 2546–53 |year= 2002 |pmid= 12239168 |doi= 10.1182/blood-2002-03-0819
*cite journal | author=Lim S, Zou Y, Friedman E |title=The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49438–45 |year= 2003 |pmid= 12384504 |doi= 10.1074/jbc.M206840200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Naderi J, Hung M, Pandey S |title=Oxidative stress-induced apoptosis in dividing fibroblasts involves activation of p38 MAP kinase and over-expression of Bax: resistance of quiescent cells to oxidative stress. |journal=Apoptosis |volume=8 |issue= 1 |pages= 91–100 |year= 2003 |pmid= 12510156 |doi=
*cite journal | author=Stringaris AK, Geisenhainer J, Bergmann F, "et al." |title=Neurotoxicity of pneumolysin, a major pneumococcal virulence factor, involves calcium influx and depends on activation of p38 mitogen-activated protein kinase. |journal=Neurobiol. Dis. |volume=11 |issue= 3 |pages= 355–68 |year= 2003 |pmid= 12586546 |doi=

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