Polypyrimidine tract binding protein 1, also known as PTBP1, is a human gene.cite web | title = Entrez Gene: PTBP1 polypyrimidine tract binding protein 1| url =| accessdate = ]

section_title =
summary_text = This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.cite web | title = Entrez Gene: PTBP1 polypyrimidine tract binding protein 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Rasmussen HH, van Damme J, Puype M, "et al." |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=
*cite journal | author=Ghetti A, Piñol-Roma S, Michael WM, "et al." |title=hnRNP I, the polypyrimidine tract-binding protein: distinct nuclear localization and association with hnRNAs. |journal=Nucleic Acids Res. |volume=20 |issue= 14 |pages= 3671–8 |year= 1992 |pmid= 1641332 |doi=
*cite journal | author=Gil A, Sharp PA, Jamison SF, Garcia-Blanco MA |title=Characterization of cDNAs encoding the polypyrimidine tract-binding protein. |journal=Genes Dev. |volume=5 |issue= 7 |pages= 1224–36 |year= 1991 |pmid= 1906035 |doi=
*cite journal | author=Patton JG, Mayer SA, Tempst P, Nadal-Ginard B |title=Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. |journal=Genes Dev. |volume=5 |issue= 7 |pages= 1237–51 |year= 1991 |pmid= 1906036 |doi=
*cite journal | author=Raimondi E, Romanelli MG, Moralli D, "et al." |title=Assignment of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein I (PTB) to chromosome 14q23-q24.1. |journal=Genomics |volume=27 |issue= 3 |pages= 553–5 |year= 1995 |pmid= 7558043 |doi= 10.1006/geno.1995.1093
*cite journal | author=Patton JG, Porro EB, Galceran J, "et al." |title=Cloning and characterization of PSF, a novel pre-mRNA splicing factor. |journal=Genes Dev. |volume=7 |issue= 3 |pages= 393–406 |year= 1993 |pmid= 8449401 |doi=
*cite journal | author=Wu-Baer F, Lane WS, Gaynor RB |title=Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4201–8 |year= 1996 |pmid= 8626763 |doi=
*cite journal | author=Black AC, Luo J, Chun S, "et al." |title=Specific binding of polypyrimidine tract binding protein and hnRNP A1 to HIV-1 CRS elements. |journal=Virus Genes |volume=12 |issue= 3 |pages= 275–85 |year= 1997 |pmid= 8883365 |doi=
*cite journal | author=Huang S, Deerinck TJ, Ellisman MH, Spector DL |title=The dynamic organization of the perinucleolar compartment in the cell nucleus. |journal=J. Cell Biol. |volume=137 |issue= 5 |pages= 965–74 |year= 1997 |pmid= 9166399 |doi=
*cite journal | author=Oh YL, Hahm B, Kim YK, "et al." |title=Determination of functional domains in polypyrimidine-tract-binding protein. |journal=Biochem. J. |volume=331 ( Pt 1) |issue= |pages= 169–75 |year= 1998 |pmid= 9512476 |doi=
*cite journal | author=Hahm B, Cho OH, Kim JE, "et al." |title=Polypyrimidine tract-binding protein interacts with HnRNP L. |journal=FEBS Lett. |volume=425 |issue= 3 |pages= 401–6 |year= 1998 |pmid= 9563502 |doi=
*cite journal | author=Meissner M, Dechat T, Gerner C, "et al." |title=Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB. |journal=J. Cell. Biochem. |volume=76 |issue= 4 |pages= 559–66 |year= 2000 |pmid= 10653975 |doi=
*cite journal | author=Kim JH, Hahm B, Kim YK, "et al." |title=Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm. |journal=J. Mol. Biol. |volume=298 |issue= 3 |pages= 395–405 |year= 2000 |pmid= 10772858 |doi= 10.1006/jmbi.2000.3687
*cite journal | author=Conte MR, Grüne T, Ghuman J, "et al." |title=Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold. |journal=EMBO J. |volume=19 |issue= 12 |pages= 3132–41 |year= 2000 |pmid= 10856256 |doi= 10.1093/emboj/19.12.3132
*cite journal | author=Markovtsov V, Nikolic JM, Goldman JA, "et al." |title=Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 20 |pages= 7463–79 |year= 2000 |pmid= 11003644 |doi=
*cite journal | author=Romanelli MG, Lorenzi P, Morandi C |title=Organization of the human gene encoding heterogeneous nuclear ribonucleoprotein type I (hnRNP I) and characterization of hnRNP I related pseudogene. |journal=Gene |volume=255 |issue= 2 |pages= 267–72 |year= 2000 |pmid= 11024286 |doi=
*cite journal | author=de Vries H, Rüegsegger U, Hübner W, "et al." |title=Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895–904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895
*cite journal | author=Zang WQ, Li B, Huang PY, "et al." |title=Role of polypyrimidine tract binding protein in the function of the hepatitis B virus posttranscriptional regulatory element. |journal=J. Virol. |volume=75 |issue= 22 |pages= 10779–86 |year= 2001 |pmid= 11602719 |doi= 10.1128/JVI.75.22.10779-10786.2001
*cite journal | author=Hüttelmaier S, Illenberger S, Grosheva I, "et al." |title=Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins. |journal=J. Cell Biol. |volume=155 |issue= 5 |pages= 775–86 |year= 2002 |pmid= 11724819 |doi= 10.1083/jcb.200105044
*cite journal | author=Kamath RV, Leary DJ, Huang S |title=Nucleocytoplasmic shuttling of polypyrimidine tract-binding protein is uncoupled from RNA export. |journal=Mol. Biol. Cell |volume=12 |issue= 12 |pages= 3808–20 |year= 2002 |pmid= 11739782 |doi=

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Cell nucleus — HeLa cells stained for the cell nucleus DNA with the Blue Hoechst dye. The central and rightmost cell are in interphase, thus their entire nuclei are labeled. On the left, a cell is going through mitosis and its DNA has condensed ready for… …   Wikipedia

  • Chromatin — The major structures in DNA compaction; DNA, the nucleosome, the 10nm beads on a string fibre, the 30nm fibre and the metaphase chromosome Chromatin is the combination of DNA and proteins that make up the contents of the nucleus of a cell. The… …   Wikipedia

  • Nuclear pore — Diagram of human cell nucleus. Nuclear pore labeled at bottom left …   Wikipedia

  • Nucleolus — The nucleolus is contained within the cell nucleus …   Wikipedia

  • Nucleoplasm — Similar to the cytoplasm of a cell, the nucleus contains nucleoplasm (nucleus sap) or karyoplasm. The nucleoplasm is one of the types of protoplasm, and it is enveloped by the nuclear membrane or nuclear envelope. The nucleoplasm is a highly… …   Wikipedia

  • Nuclear lamina — The nuclear lamina is a dense ( 30 to 100 nm thick) fibrillar network inside the nucleus of a eukaryotic cell. It is composed of intermediate filaments and membrane associated proteins. Besides providing mechanical support, the nuclear lamina… …   Wikipedia

  • Condensin — Condensins are large protein complexes that play a central role in chromosome assembly and segregation in eukaryotic cells. Contents 1 Subunit composition 2 Evolution 3 Subcellular localization and regulation …   Wikipedia

  • Cajal body — Nuclei of mouse cells (blue) containing Cajal bodies (green) visualized by fusion of p80/Coilin protein to GFP. Cajal bodies (CBs) are spherical sub organelles of 0.3 1.0 µm in diameter found in the nucleus of proliferative cells like embryonic… …   Wikipedia

  • Nuclear matrix — In biology, the nuclear matrix is the network of fibres found throughout the inside of a cell nucleus and is somewhat analogous to the cell cytoskeleton. However, in contrast to the cytoskeleton, the nuclear matrix has been proposed to be a… …   Wikipedia

  • Nucleolus organizer region — The nucleolus organizer region (NOR) or nucleolar organizer is a chromosomal region around which the nucleolus forms. This region is the particular part of a chromosome that is associated with a nucleolus after the nucleus divides. The region… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.