FTH1


FTH1

Ferritin, heavy polypeptide 1, also known as FTH1, is a human gene.cite web | title = Entrez Gene: FTH1 ferritin, heavy polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2495| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.cite web | title = Entrez Gene: FTH1 ferritin, heavy polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2495| accessdate = ]

ee also

* Ferritin

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Percy ME, Wong S, Bauer S, "et al." |title=Iron metabolism and human ferritin heavy chain cDNA from adult brain with an elongated untranslated region: new findings and insights. |journal=The Analyst |volume=123 |issue= 1 |pages= 41–50 |year= 1998 |pmid= 9581019 |doi=
*cite journal | author=Arosio P, Adelman TG, Drysdale JW |title=On ferritin heterogeneity. Further evidence for heteropolymers. |journal=J. Biol. Chem. |volume=253 |issue= 12 |pages= 4451–8 |year= 1978 |pmid= 659425 |doi=
*cite journal | author=Lawson DM, Artymiuk PJ, Yewdall SJ, "et al." |title=Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts. |journal=Nature |volume=349 |issue= 6309 |pages= 541–4 |year= 1991 |pmid= 1992356 |doi= 10.1038/349541a0
*cite journal | author=Costanzo F, Colombo M, Staempfli S, "et al." |title=Structure of gene and pseudogenes of human apoferritin H. |journal=Nucleic Acids Res. |volume=14 |issue= 2 |pages= 721–36 |year= 1986 |pmid= 3003694 |doi=
*cite journal | author=Hentze MW, Keim S, Papadopoulos P, "et al." |title=Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 19 |pages= 7226–30 |year= 1986 |pmid= 3020541 |doi=
*cite journal | author=Chou CC, Gatti RA, Fuller ML, "et al." |title=Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro. |journal=Mol. Cell. Biol. |volume=6 |issue= 2 |pages= 566–73 |year= 1987 |pmid= 3023856 |doi=
*cite journal | author=Hentze MW, Caughman SW, Rouault TA, "et al." |title=Identification of the iron-responsive element for the translational regulation of human ferritin mRNA. |journal=Science |volume=238 |issue= 4833 |pages= 1570–3 |year= 1988 |pmid= 3685996 |doi=
*cite journal | author=Boyd D, Vecoli C, Belcher DM, "et al." |title=Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones. |journal=J. Biol. Chem. |volume=260 |issue= 21 |pages= 11755–61 |year= 1985 |pmid= 3840162 |doi=
*cite journal | author=Worwood M, Brook JD, Cragg SJ, "et al." |title=Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qter. |journal=Hum. Genet. |volume=69 |issue= 4 |pages= 371–4 |year= 1985 |pmid= 3857215 |doi=
*cite journal | author=Dörner MH, Salfeld J, Will H, "et al." |title=Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 10 |pages= 3139–43 |year= 1985 |pmid= 3858810 |doi=
*cite journal | author=Costanzo F, Santoro C, Colantuoni V, "et al." |title=Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family. |journal=EMBO J. |volume=3 |issue= 1 |pages= 23–7 |year= 1984 |pmid= 6323167 |doi=
*cite journal | author=Boyd D, Jain SK, Crampton J, "et al." |title=Isolation and characterization of a cDNA clone for human ferritin heavy chain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=81 |issue= 15 |pages= 4751–5 |year= 1984 |pmid= 6589621 |doi=
*cite journal | author=Addison JM, Fitton JE, Lewis WG, "et al." |title=The amino acid sequence of human liver apoferritin. |journal=FEBS Lett. |volume=164 |issue= 1 |pages= 139–44 |year= 1984 |pmid= 6653779 |doi=
*cite journal | author=Dhar MS, Joshi JG |title=Differential processing of the ferritin heavy chain mRNA in human liver and adult human brain. |journal=J. Neurochem. |volume=61 |issue= 6 |pages= 2140–6 |year= 1993 |pmid= 7504084 |doi=
*cite journal | author=Connor JR, Snyder BS, Arosio P, "et al." |title=A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains. |journal=J. Neurochem. |volume=65 |issue= 2 |pages= 717–24 |year= 1995 |pmid= 7616228 |doi=
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Dhar M, Chauthaiwale V, Joshi JG |title=Sequence of a cDNA encoding the ferritin H-chain from an 11-week-old human fetal brain. |journal=Gene |volume=126 |issue= 2 |pages= 275–8 |year= 1993 |pmid= 7916709 |doi=
*cite journal | author=Qi Y, Dawson G |title=Hypoxia specifically and reversibly induces the synthesis of ferritin in oligodendrocytes and human oligodendrogliomas. |journal=J. Neurochem. |volume=63 |issue= 4 |pages= 1485–90 |year= 1994 |pmid= 7931301 |doi=
*cite journal | author=Rogers JT |title=Ferritin translation by interleukin-1and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes. |journal=Blood |volume=87 |issue= 6 |pages= 2525–37 |year= 1996 |pmid= 8630420 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=

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