Interleukin 17A, also known as IL17A, is a human gene.cite web | title = Entrez Gene: IL17A interleukin 17A| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.cite web | title = Entrez Gene: IL17A interleukin 17A| url =| accessdate = ]

ee also

* Interleukin 17


Further reading

citations =
*cite journal | author=Gaffen SL |title=Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis. |journal=Arthritis Res. Ther. |volume=6 |issue= 6 |pages= 240–7 |year= 2005 |pmid= 15535837 |doi= 10.1186/ar1444
*cite journal | author=Lubberts E, Koenders MI, van den Berg WB |title=The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models. |journal=Arthritis Res. Ther. |volume=7 |issue= 1 |pages= 29–37 |year= 2006 |pmid= 15642151 |doi= 10.1186/ar1478
*cite journal | author=Yao Z, Painter SL, Fanslow WC, "et al." |title=Human IL-17: a novel cytokine derived from T cells. |journal=J. Immunol. |volume=155 |issue= 12 |pages= 5483–6 |year= 1996 |pmid= 7499828 |doi=
*cite journal | author=Rouvier E, Luciani MF, Mattéi MG, "et al." |title=CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. |journal=J. Immunol. |volume=150 |issue= 12 |pages= 5445–56 |year= 1993 |pmid= 8390535 |doi=
*cite journal | author=Fossiez F, Djossou O, Chomarat P, "et al." |title=T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. |journal=J. Exp. Med. |volume=183 |issue= 6 |pages= 2593–603 |year= 1996 |pmid= 8676080 |doi=
*cite journal | author=Yao Z, Spriggs MK, Derry JM, "et al." |title=Molecular characterization of the human interleukin (IL)-17 receptor. |journal=Cytokine |volume=9 |issue= 11 |pages= 794–800 |year= 1998 |pmid= 9367539 |doi=
*cite journal | author=Murphy KP, Gagne P, Pazmany C, Moody MD |title=Expression of human interleukin-17 in Pichia pastoris: purification and characterization. |journal=Protein Expr. Purif. |volume=12 |issue= 2 |pages= 208–14 |year= 1998 |pmid= 9518462 |doi= 10.1006/prep.1997.0832
*cite journal | author=Teunissen MB, Koomen CW, de Waal Malefyt R, "et al." |title=Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. |journal=J. Invest. Dermatol. |volume=111 |issue= 4 |pages= 645–9 |year= 1998 |pmid= 9764847 |doi= 10.1046/j.1523-1747.1998.00347.x
*cite journal | author=Shalom-Barak T, Quach J, Lotz M |title=Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27467–73 |year= 1998 |pmid= 9765276 |doi=
*cite journal | author=Shin HC, Benbernou N, Fekkar H, "et al." |title=Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. |journal=Cytokine |volume=10 |issue= 11 |pages= 841–50 |year= 1999 |pmid= 9878122 |doi= 10.1006/cyto.1998.0375
*cite journal | author=Laan M, Cui ZH, Hoshino H, "et al." |title=Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. |journal=J. Immunol. |volume=162 |issue= 4 |pages= 2347–52 |year= 1999 |pmid= 9973514 |doi=
*cite journal | author=Kotake S, Udagawa N, Takahashi N, "et al." |title=IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. |journal=J. Clin. Invest. |volume=103 |issue= 9 |pages= 1345–52 |year= 1999 |pmid= 10225978 |doi=
*cite journal | author=Shin HC, Benbernou N, Esnault S, Guenounou M |title=Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. |journal=Cytokine |volume=11 |issue= 4 |pages= 257–66 |year= 1999 |pmid= 10328864 |doi= 10.1006/cyto.1998.0433
*cite journal | author=Andoh A, Takaya H, Makino J, "et al." |title=Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells. |journal=Clin. Exp. Immunol. |volume=125 |issue= 1 |pages= 56–63 |year= 2001 |pmid= 11472426 |doi=
*cite journal | author=Laan M, Palmberg L, Larsson K, Lindén A |title=Free, soluble interleukin-17 protein during severe inflammation in human airways. |journal=Eur. Respir. J. |volume=19 |issue= 3 |pages= 534–7 |year= 2002 |pmid= 11936535 |doi=
*cite journal | author=Andoh A, Fujino S, Bamba S, "et al." |title=IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. |journal=J. Immunol. |volume=169 |issue= 4 |pages= 1683–7 |year= 2002 |pmid= 12165487 |doi=
*cite journal | author=Andoh A, Shimada M, Bamba S, "et al." |title=Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts. |journal=Biochim. Biophys. Acta |volume=1591 |issue= 1-3 |pages= 69–74 |year= 2002 |pmid= 12183057 |doi=
*cite journal | author=Hsieh HG, Loong CC, Lin CY |title=Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells. |journal=Cytokine |volume=19 |issue= 4 |pages= 159–74 |year= 2003 |pmid= 12297109 |doi=
*cite journal | author=Aggarwal S, Ghilardi N, Xie MH, "et al." |title=Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1910–4 |year= 2003 |pmid= 12417590 |doi= 10.1074/jbc.M207577200
*cite journal | author=Maertzdorf J, Osterhaus AD, Verjans GM |title=IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. |journal=J. Immunol. |volume=169 |issue= 10 |pages= 5897–903 |year= 2003 |pmid= 12421973 |doi=

update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • Haematopoiesis — Diagram showing the development of different blood cells from haematopoietic stem cell to mature cells Haematopoiesis (from Ancient Greek: αἷμα, blood ; ποιεῖν to make ) (or hematopoiesis in the United States; sometimes also haemopoiesis or… …   Wikipedia

  • Cytokine — Cytokines (Greek cyto , cell; and kinos, movement) are small cell signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of the immune system and are a category of signaling molecules used… …   Wikipedia

  • Chemokine — Small cytokines (intecrine/chemokine), interleukin 8 like Solution structure of interleukin 8, a chemokine of the CXC subfamily Identifiers Symbol IL8 …   Wikipedia

  • Interleukin 6 — (interferon, beta 2) PDB rendering based on 1ALU …   Wikipedia

  • Peginterferon alfa-2a — Clinical data AHFS/ Consumer Drug Information MedlinePlus …   Wikipedia

  • Osteopontin — Secreted phosphoprotein 1 Rendering based on PDB 3CXD …   Wikipedia

  • Leukemia inhibitory factor — (cholinergic differentiation factor) PDB rendering based on 1LKI …   Wikipedia

  • CCL2 — For the ICAO airport code see Candle Lake Airpark, for the diradical compound see Dichlorocarbene. Chemokine (C C motif) ligand 2 PDB rendering based on 1dok …   Wikipedia

  • Colony-stimulating factor — Colony stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate… …   Wikipedia

  • CCL5 — Chemokine (C C motif) ligand 5 PDB rendering based on 1pmi …   Wikipedia