Fusion gene

Fusion gene

A fusion gene is a hybrid gene formed from two previously separate genes. It can occur as the result of a translocation, interstitial deletion, or chromosomal inversion. The fusion of two genes is often taken as evidence that these genes have related functions [ [http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=165481] Christian von Mering,1,2 Martijn Huynen,3 Daniel Jaeggi,1,2 Steffen Schmidt,1,2 Peer Bork,1,2* and Berend Snel3. (2003). STRING: a database of predicted functional associations between proteins. Nucleic Acids Res.31(1): 258–261.] . Often, fusion genes are oncogenes; examples include BCR-ABL, FIG-ROS, TEL-AML1 (ALL with t(12 ; 21)), AML1-ETO (M2 AML with t(8 ; 21)) and TEL-JAK2.

Biologists may also deliberately create fusion genes for research purposes. For example, by creating a fusion gene of a protein of interest and green fluorescent protein, the protein of interest may be observed in cells or tissue using fluorescence microscopy. The protein synthesized when a fusion gene is expressed is called a "fusion protein".

References


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • fusion gene — fusion gene. См. гибридный ген. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • fusion gene — See: chimeric gene …   Glossary of Biotechnology

  • Fusion protein — This article is about chimeric fusion proteins. For proteins involved in membrane fusion, see membrane fusion protein. Fusion proteins or chimeric proteins are proteins created through the joining of two or more genes which originally coded for… …   Wikipedia

  • Gène — Pour les articles homonymes, voir Gène (homonymie). Représentation simplifiée d un gène d eucaryote (les exons sont des séquences codantes, alors que les introns sont des séquences non codantes) …   Wikipédia en Français

  • Gene therapy — using an Adenovirus vector. A new gene is inserted into an adenovirull. If the treatment is successful, the new gene will make a functional protein. Gene therapy is the insertion, alteration, or removal of genes within an individual s cells and… …   Wikipedia

  • Gene trapping — is a high throughput approach that is used to introduce insertional mutations across the mammalian genome. It is performed with gene trap vectors whose principal element is a gene trapping cassette consisting of a promoterless reporter gene… …   Wikipedia

  • Fusion — can refer to combining two or more distinct things *Cell fusion *Freezing, a chemistry term for a liquid undergoing a phase change into a solid *Gene fusion, a genetic event and molecular biology technique *Nuclear fusion, the process by which… …   Wikipedia

  • Fusion Fire — is a science fiction novel by Kathy Tyers originally published in 1987, and later rewritten and republished in 2000. The protagonist is Lady Firebird Angelo, once a wastling of a Netaian royal family and now a Federate citizen.Plot summaryThe… …   Wikipedia

  • Gene Perla — (* 1. März 1940 in Hackensack/New Jersey) ist ein US amerikanischer Jazz Bassist. Perla lernte zunächst Klavier, spielte dann während seiner Zeit in der Highschool Posaune. Er unterzog sich zunächst einem Studium als Wirtschaftsingenieur an der… …   Deutsch Wikipedia

  • Fusion power — The Sun is a natural fusion reactor. Fusion power is the power generated by nuclear fusion processes. In fusion reactions two light atomic nuclei fuse together to form a heavier nucleus (in contrast with fission power). In doing so they release a …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”