CDH1 (gene)


CDH1 (gene)

Cadherin 1, type 1, E-cadherin (epithelial), also known as CDH1, is a human gene. CDH1 has also been designated as CD324 (cluster of differentiation 324).

It is a tumor suppressor gene.cite journal |author=Semb H, Christofori G |title=The tumor-suppressor function of E-cadherin |journal=Am. J. Hum. Genet. |volume=63 |issue=6 |pages=1588–93 |year=1998 |month=December |pmid=9837810 |pmc=1377629 |doi=10.1086/302173 |url=http://linkinghub.elsevier.com/retrieve/pii/S0002-9297(07)61602-4] cite journal |author=Wong AS, Gumbiner BM |title=Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin |journal=J. Cell Biol. |volume=161 |issue=6 |pages=1191–203 |year=2003 |month=June |pmid=12810698 |pmc=2173007 |doi=10.1083/jcb.200212033 |url=http://www.jcb.org/cgi/pmidlookup?view=long&pmid=12810698]

PBB_Summary
section_title =
summary_text = This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [cite web | title = Entrez Gene: CDH1 cadherin 1, type 1, E-cadherin (epithelial)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=999| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Berx G, Becker KF, Höfler H, van Roy F |title=Mutations of the human E-cadherin (CDH1) gene. |journal=Hum. Mutat. |volume=12 |issue= 4 |pages= 226–37 |year= 1998 |pmid= 9744472 |doi= 10.1002/(SICI)1098-1004(1998)12:4<226::AID-HUMU2>3.0.CO;2-D |doilabel=10.1002/(SICI)1098-1004(1998)12:4226::AID-HUMU23.0.CO;2-D
*cite journal | author=Wijnhoven BP, Dinjens WN, Pignatelli M |title=E-cadherin-catenin cell-cell adhesion complex and human cancer. |journal=The British journal of surgery |volume=87 |issue= 8 |pages= 992–1005 |year= 2000 |pmid= 10931041 |doi= 10.1046/j.1365-2168.2000.01513.x
*cite journal | author=Beavon IR |title=The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation. |journal=Eur. J. Cancer |volume=36 |issue= 13 Spec No |pages= 1607–20 |year= 2000 |pmid= 10959047 |doi=
*cite journal | author=Wilson PD |title=Polycystin: new aspects of structure, function, and regulation. |journal=J. Am. Soc. Nephrol. |volume=12 |issue= 4 |pages= 834–45 |year= 2001 |pmid= 11274246 |doi=
*cite journal | author=Chun YS, Lindor NM, Smyrk TC, "et al." |title=Germline E-cadherin gene mutations: is prophylactic total gastrectomy indicated? |journal=Cancer |volume=92 |issue= 1 |pages= 181–7 |year= 2001 |pmid= 11443625 |doi=
*cite journal | author=Hazan RB, Qiao R, Keren R, "et al." |title=Cadherin switch in tumor progression. |journal=Ann. N. Y. Acad. Sci. |volume=1014 |issue= |pages= 155–63 |year= 2004 |pmid= 15153430 |doi=
*cite journal | author=Bryant DM, Stow JL |title=The ins and outs of E-cadherin trafficking. |journal=Trends Cell Biol. |volume=14 |issue= 8 |pages= 427–34 |year= 2005 |pmid= 15308209 |doi= 10.1016/j.tcb.2004.07.007
*cite journal | author=Wang HD, Ren J, Zhang L |title=CDH1 germline mutation in hereditary gastric carcinoma. |journal=World J. Gastroenterol. |volume=10 |issue= 21 |pages= 3088–93 |year= 2004 |pmid= 15457549 |doi=
*cite journal | author=Reynolds AB, Carnahan RH |title=Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. |journal=Semin. Cell Dev. Biol. |volume=15 |issue= 6 |pages= 657–63 |year= 2005 |pmid= 15561585 |doi= 10.1016/j.semcdb.2004.09.003
*cite journal | author=Moran CJ, Joyce M, McAnena OJ |title=CDH1 associated gastric cancer: a report of a family and review of the literature. |journal=Eur J Surg Oncol |volume=31 |issue= 3 |pages= 259–64 |year= 2005 |pmid= 15780560 |doi= 10.1016/j.ejso.2004.12.010
*cite journal | author=Georgolios A, Batistatou A, Manolopoulos L, Charalabopoulos K |title=Role and expression patterns of E-cadherin in head and neck squamous cell carcinoma (HNSCC). |journal=J. Exp. Clin. Cancer Res. |volume=25 |issue= 1 |pages= 5–14 |year= 2006 |pmid= 16761612 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Look at other dictionaries:

  • CDH1 — may refer to: * Huntsville/Deerhurst Resort Airport * CDH1 (gene) …   Wikipedia

  • p16 (gene) — Cyclin dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) PDB rendering based on 1a5e …   Wikipedia

  • Cadherin — Cadherins are a class of type 1 transmembrane proteins. They play important roles in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium (Ca2+) ions to function, hence their name.The cadherin… …   Wikipedia

  • FZR1 — Fizzy/cell division cycle 20 related 1 (Drosophila), also known as FZR1, is a human gene.cite web | title = Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Punto de control de la mitosis — La comprensión de cómo las células mantienen constante el número apropiado de cromosomas después de cada división celular es una cuestión fascinante. Un único error que dé lugar a células con más o menos cromosomas de los que deber tener (una… …   Wikipedia Español

  • ANAPC2 — Anaphase promoting complex subunit 2, also known as ANAPC2, is a human gene.cite web | title = Entrez Gene: ANAPC2 anaphase promoting complex subunit 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=29882| …   Wikipedia

  • E-кадгерин — E кадгерин, кадгерин 1 Структура молекулы E кадгерина Обозначения …   Википедия

  • c-Met — Met proto oncogene (hepatocyte growth factor receptor) Crystallographic structure of MET. PDB rendering based on 1r0p …   Wikipedia

  • Mothers against decapentaplegic homolog 2 — SMAD family member 2 PDB rendering based on 1dev …   Wikipedia

  • CDC23 — Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a human gene.cite web | title = Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia


Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”

We are using cookies for the best presentation of our site. Continuing to use this site, you agree with this.