Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), also known as TAP2, is a human gene.

section_title =
summary_text = The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [cite web | title = Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6891| accessdate = ]

ee also

* ATP-binding cassette transporter


Further reading

citations =
*cite journal | author=Townsend A, Trowsdale J |title=The transporters associated with antigen presentation. |journal=Semin. Cell Biol. |volume=4 |issue= 1 |pages= 53–61 |year= 1993 |pmid= 8453065 |doi=
*cite journal | author=Beck S, Kelly A, Radley E, "et al." |title=DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. |journal=J. Mol. Biol. |volume=228 |issue= 2 |pages= 433–41 |year= 1992 |pmid= 1453454 |doi=
*cite journal | author=Bodmer JG, Marsh SG, Albert ED, "et al." |title=Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. |journal=Tissue Antigens |volume=39 |issue= 4 |pages= 161–73 |year= 1992 |pmid= 1529427 |doi=
*cite journal | author=Kelly A, Powis SH, Kerr LA, "et al." |title=Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. |journal=Nature |volume=355 |issue= 6361 |pages= 641–4 |year= 1992 |pmid= 1538751 |doi= 10.1038/355641a0
*cite journal | author=Colonna M, Bresnahan M, Bahram S, "et al." |title=Allelic variants of the human putative peptide transporter involved in antigen processing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 9 |pages= 3932–6 |year= 1992 |pmid= 1570316 |doi=
*cite journal | author=Powis SH, Mockridge I, Kelly A, "et al." |title=Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1463–7 |year= 1992 |pmid= 1741401 |doi=
*cite journal | author=Bahram S, Arnold D, Bresnahan M, "et al." |title=Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 22 |pages= 10094–8 |year= 1991 |pmid= 1946428 |doi=
*cite journal | author=Trowsdale J, Hanson I, Mockridge I, "et al." |title=Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. |journal=Nature |volume=348 |issue= 6303 |pages= 741–4 |year= 1991 |pmid= 2259383 |doi= 10.1038/348741a0
*cite journal | author=de la Salle H, Hanau D, Fricker D, "et al." |title=Homozygous human TAP peptide transporter mutation in HLA class I deficiency. |journal=Science |volume=265 |issue= 5169 |pages= 237–41 |year= 1994 |pmid= 7517574 |doi=
*cite journal | author=Cano P, Baxter-Lowe LA |title=Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain. |journal=Tissue Antigens |volume=45 |issue= 2 |pages= 139–42 |year= 1995 |pmid= 7792761 |doi=
*cite journal | author=Roby KF, Fei K, Yang Y, Hunt JS |title=Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines. |journal=Immunology |volume=83 |issue= 3 |pages= 444–8 |year= 1995 |pmid= 7835969 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Singal DP, Ye M, Qiu X, D'Souza M |title=Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis. |journal=Clin. Exp. Rheumatol. |volume=12 |issue= 1 |pages= 29–33 |year= 1994 |pmid= 8162639 |doi=
*cite journal | author=Powis SH, Tonks S, Mockridge I, "et al." |title=Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. |journal=Immunogenetics |volume=37 |issue= 5 |pages= 373–80 |year= 1993 |pmid= 8428770 |doi=
*cite journal | author=Glynne R, Kerr LA, Mockridge I, "et al." |title=The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing. |journal=Eur. J. Immunol. |volume=23 |issue= 4 |pages= 860–6 |year= 1993 |pmid= 8458375 |doi=
*cite journal | author=Beck S, Abdulla S, Alderton RP, "et al." |title=Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. |journal=J. Mol. Biol. |volume=255 |issue= 1 |pages= 1–13 |year= 1996 |pmid= 8568858 |doi= 10.1006/jmbi.1996.0001
*cite journal | author=Ahn K, Meyer TH, Uebel S, "et al." |title=Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. |journal=EMBO J. |volume=15 |issue= 13 |pages= 3247–55 |year= 1996 |pmid= 8670825 |doi=
*cite journal | author=Pattanakitsakul S, Takeuchi F, Nabeta H, "et al." |title=A novel TAP 2 gene RFLP observed in a Japanese. |journal=Tissue Antigens |volume=47 |issue= 4 |pages= 353–5 |year= 1996 |pmid= 8773329 |doi=
*cite journal | author=Lewis JW, Neisig A, Neefjes J, Elliott T |title=Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP. |journal=Curr. Biol. |volume=6 |issue= 7 |pages= 873–83 |year= 1997 |pmid= 8805302 |doi=

External links


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