Engrailed (gene)


Engrailed (gene)

Engrailed is a gene involved in many aspects of multicellular development. First known for its role in arthropod embryological development, working in consort with the Hox genes, Engrailed has been found to be important in other areas of development. It has also been found to direct development in other taxa, for example: humans.

Protein

The gene Engrailed (En) codes for the homeodomain-containing transcription factor protein "engrailed." Homologous engrailed proteins are found in a diversity of organisms.

Arthropods

In the model organism "Drosophila melanogaster" Engrailed acts as a segment-polarity gene in early embryonic development. It is initially expressed in stage 10-11 of development in 14 isolated bands of cells along the embryo's anterior-posterior axis. The cells expressing Engrailed define the posterior most region of each parasegment. Once proper segments form, Engrailed expressing cells are found in the anterior most region of each segment. [Sanson, B. (2001). Generating patterns from fields of cells. "EMBO reports" 2(12):1083-1088]

Engrailed homologs have also been found in many other arthropod species including: grasshoppers, milkweed bugs, centipedes, beetles, and others.

Neurological Development

Engrailed plays a number of crucial roles in brain development across many species. Some of these include determining the hindbrain/midbrain border and aiding in neuronal axon guidance. [Morgan, R (2006). Engrailed: Complexity and economy of a multi-functional transcription factor. FEBS Letters 580(11):2531-3]

References

Sanson, B. (2001). Generating patterns from fields of cells. "EMBO reports" 2(12):1083-1088
Morgan, R (2006). Engrailed: Complexity and economy of a multi-functional transcription factor. FEBS Letters 580(11):2531-3


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Look at other dictionaries:

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  • engrailed — Drosophila gene that controls segmental polarity. It is the archetype for one of three subfamilies of homeobox containing genes …   Dictionary of molecular biology

  • EN2 (gene) — Engrailed homeobox 2, also known as EN2, is a human gene.cite web | title = Entrez Gene: EN2 engrailed homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=2020| accessdate = ] PBB Summary section… …   Wikipedia

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  • Compartment (development) — Compartments can be simply defined as separate, different, adjacent cell populations, which upon juxtaposition, create a lineage boundary.[1] This boundary prevents cell movement from cells from different lineages across this barrier, restricting …   Wikipedia


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