RSPO1

R-spondin homolog (Xenopus laevis), also known as RSPO1, is a human gene.cite web | title = Entrez Gene: RSPO1 R-spondin homolog (Xenopus laevis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284654| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.cite web | title = Entrez Gene: RSPO1 R-spondin homolog (Xenopus laevis)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284654| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Kamata T, Katsube K, Michikawa M, "et al." |title=R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants. |journal=Biochim. Biophys. Acta |volume=1676 |issue= 1 |pages= 51–62 |year= 2004 |pmid= 14732490 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kim KA, Kakitani M, Zhao J, "et al." |title=Mitogenic influence of human R-spondin1 on the intestinal epithelium. |journal=Science |volume=309 |issue= 5738 |pages= 1256–9 |year= 2005 |pmid= 16109882 |doi= 10.1126/science.1112521
*cite journal | author=Abraham C, Cho JH |title=Inducing intestinal growth. |journal=N. Engl. J. Med. |volume=353 |issue= 21 |pages= 2297–9 |year= 2005 |pmid= 16306530 |doi= 10.1056/NEJMcibr053367
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Parma P, Radi O, Vidal V, "et al." |title=R-spondin1 is essential in sex determination, skin differentiation and malignancy. |journal=Nat. Genet. |volume=38 |issue= 11 |pages= 1304–9 |year= 2007 |pmid= 17041600 |doi= 10.1038/ng1907
*cite journal | author=Binnerts ME, Kim KA, Bright JM, "et al." |title=R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 37 |pages= 14700–5 |year= 2007 |pmid= 17804805 |doi= 10.1073/pnas.0702305104

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