Poliovirus receptor-related 3, also known as PVRL3 and CD113 (Cluster of Differentiation 113), is a human gene.cite web | title = Entrez Gene: PVRL3 poliovirus receptor-related 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25945| accessdate = ]

section_title =
summary_text = Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells. [supplied by OMIM] cite web | title = Entrez Gene: PVRL3 poliovirus receptor-related 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25945| accessdate = ]

ee also

* Cluster of differentiation


Further reading

citations =
*cite journal | author=Satoh-Horikawa K, Nakanishi H, Takahashi K, "et al." |title=Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10291–9 |year= 2000 |pmid= 10744716 |doi=
*cite journal | author=Reymond N, Borg JP, Lecocq E, "et al." |title=Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. |journal=Gene |volume=255 |issue= 2 |pages= 347–55 |year= 2000 |pmid= 11024295 |doi=
*cite journal | author=Fabre S, Reymond N, Cocchi F, "et al." |title=Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 27006–13 |year= 2002 |pmid= 12011057 |doi= 10.1074/jbc.M203228200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Takekuni K, Ikeda W, Fujito T, "et al." |title=Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 5497–500 |year= 2003 |pmid= 12515806 |doi= 10.1074/jbc.C200707200
*cite journal | author=Mueller S, Wimmer E |title=Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 31251–60 |year= 2003 |pmid= 12759359 |doi= 10.1074/jbc.M304166200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Fujito T, Ikeda W, Kakunaga S, "et al." |title=Inhibition of cell movement and proliferation by cell-cell contact-induced interaction of Necl-5 with nectin-3. |journal=J. Cell Biol. |volume=171 |issue= 1 |pages= 165–73 |year= 2005 |pmid= 16216929 |doi= 10.1083/jcb.200501090

External links


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