MED26

Cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa, also known as CRSP7, is a human gene.cite web | title = Entrez Gene: CRSP7 cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9441| accessdate = ]

PBB_Summary
section_title =
summary_text = The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.cite web | title = Entrez Gene: CRSP7 cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9441| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ryu S, Zhou S, Ladurner AG, Tjian R |title=The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. |journal=Nature |volume=397 |issue= 6718 |pages= 446–50 |year= 1999 |pmid= 9989412 |doi= 10.1038/17141
*cite journal | author=Näär AM, Beaurang PA, Zhou S, "et al." |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789
*cite journal | author=Booth V, Koth CM, Edwards AM, Arrowsmith CH |title=Structure of a conserved domain common to the transcription factors TFIIS, elongin A, and CRSP70. |journal=J. Biol. Chem. |volume=275 |issue= 40 |pages= 31266–8 |year= 2000 |pmid= 10811649 |doi= 10.1074/jbc.M002595200
*cite journal | author=Näär AM, Taatjes DJ, Zhai W, "et al." |title=Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. |journal=Genes Dev. |volume=16 |issue= 11 |pages= 1339–44 |year= 2002 |pmid= 12050112 |doi= 10.1101/gad.987602
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sato S, Tomomori-Sato C, Banks CA, "et al." |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671–4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200
*cite journal | author=Tomomori-Sato C, Sato S, Parmely TJ, "et al." |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846–51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Mo X, Kowenz-Leutz E, Xu H, Leutz A |title=Ras induces mediator complex exchange on C/EBP beta. |journal=Mol. Cell |volume=13 |issue= 2 |pages= 241–50 |year= 2004 |pmid= 14759369 |doi=
*cite journal | author=Sato S, Tomomori-Sato C, Parmely TJ, "et al." |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685–91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006
*cite journal | author=Zhang X, Krutchinsky A, Fukuda A, "et al." |title=MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. |journal=Mol. Cell |volume=19 |issue= 1 |pages= 89–100 |year= 2005 |pmid= 15989967 |doi= 10.1016/j.molcel.2005.05.015
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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