C19orf2

Chromosome 19 open reading frame 2, also known as C19orf2, is a human gene.cite web | title = Entrez Gene: C19orf2 chromosome 19 open reading frame 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8725| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.cite web | title = Entrez Gene: C19orf2 chromosome 19 open reading frame 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8725| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dorjsuren D, Lin Y, Wei W, "et al." |title=RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7546–55 |year= 1998 |pmid= 9819440 |doi=
*cite journal | author=Van Leuven F, Torrekens S, Moechars D, "et al." |title=Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease. |journal=Genomics |volume=54 |issue= 3 |pages= 511–20 |year= 1999 |pmid= 9878255 |doi= 10.1006/geno.1998.5609
*cite journal | author=Liu L, McKeehan WL |title=Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity. |journal=Genomics |volume=79 |issue= 1 |pages= 124–36 |year= 2002 |pmid= 11827465 |doi= 10.1006/geno.2001.6679
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wei W, Gu JX, Zhu CQ, "et al." |title=Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). |journal=Cell Res. |volume=13 |issue= 2 |pages= 111–20 |year= 2003 |pmid= 12737519 |doi= 10.1038/sj.cr.7290155
*cite journal | author=Gstaiger M, Luke B, Hess D, "et al." |title=Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. |journal=Science |volume=302 |issue= 5648 |pages= 1208–12 |year= 2003 |pmid= 14615539 |doi= 10.1126/science.1088401
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Delgermaa L, Hayashi N, Dorjsuren D, "et al." |title=Subcellular localization of RPB5-mediating protein and its putative functional partner. |journal=Mol. Cell. Biol. |volume=24 |issue= 19 |pages= 8556–66 |year= 2004 |pmid= 15367675 |doi= 10.1128/MCB.24.19.8556-8566.2004
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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