ARHGAP8


ARHGAP8

Rho GTPase activating protein 8, also known as ARHGAP8, is a human gene.cite web | title = Entrez Gene: ARHGAP8 Rho GTPase activating protein 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23779| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.cite web | title = Entrez Gene: ARHGAP8 Rho GTPase activating protein 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23779| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Peck J, Douglas G, Wu CH, Burbelo PD |title=Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. |journal=FEBS Lett. |volume=528 |issue= 1-3 |pages= 27–34 |year= 2002 |pmid= 12297274 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shan Z, Haaf T, Popescu NC |title=Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8. |journal=Gene |volume=303 |issue= |pages= 55–61 |year= 2003 |pmid= 12559566 |doi=
*cite journal | author=Shang X, Zhou YT, Low BC |title=Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1. |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 45903–14 |year= 2003 |pmid= 12944407 |doi= 10.1074/jbc.M304514200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Lua BL, Low BC |title=BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration. |journal=Mol. Biol. Cell |volume=15 |issue= 6 |pages= 2873–83 |year= 2004 |pmid= 15064355 |doi= 10.1091/mbc.E04-02-0141
*cite journal | author=Johnstone CN, Castellví-Bel S, Chang LM, "et al." |title=ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOG
journal=Gene |volume=336 |issue= 1 |pages= 59–71 |year= 2004 |pmid= 15225876 |doi= 10.1016/j.gene.2004.01.025

*cite journal | author=Lua BL, Low BC |title=Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 6 |pages= 1110–2 |year= 2005 |pmid= 15506981 |doi= 10.1042/BST0321110
*cite journal | author=Lua BL, Low BC |title=Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain. |journal=J. Cell. Sci. |volume=118 |issue= Pt 12 |pages= 2707–21 |year= 2005 |pmid= 15944398 |doi= 10.1242/jcs.02383

PBB_Controls
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  • RhoGAP domain — Pfam box Symbol = RhoGAP Name = RhoGAP domain width = caption = Pfam= PF00620 InterPro= IPR000198 SMART= RhoGAP PROSITE= PDOC50238 SCOP = 1rgb TCDB = OPM family= OPM protein= 1xa6 PDB=PDB3|1xa6A:291 444 PDB3|1f7cA:199 355 PDB3|1am4B:260… …   Wikipedia