NODAL modulator 1
Symbols NOMO1; NOMO3; Nomo; PM5
External IDs OMIM609157 MGI2385850 HomoloGene13810 GeneCards: NOMO1 Gene
Species Human Mouse
Entrez 23420 211548
Ensembl ENSG00000103512 ENSMUSG00000030835
UniProt Q15155 n/a
RefSeq (mRNA) NM_014287 NM_153057.4
RefSeq (protein) NP_055102 NP_694697.3
Location (UCSC) Chr 16:
14.93 – 14.99 Mb
Chr 7:
53.29 – 53.34 Mb
PubMed search [1] [2]

Nodal modulator 1 is a protein that in humans is encoded by the NOMO1 gene.[1][2][3]

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE).[3]


  1. ^ Templeton NS, Rodgers LA, Levy AT, Ting KL, Krutzsch HC, Liotta LA, Stetler-Stevenson WG (Mar 1992). "Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family". Genomics 12 (1): 175–6. doi:10.1016/0888-7543(92)90425-R. PMID 1310294. 
  2. ^ Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C (Aug 2004). "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists". EMBO J 23 (15): 3041–50. doi:10.1038/sj.emboj.7600307. PMC 514924. PMID 15257293. 
  3. ^ a b "Entrez Gene: NOMO1 NODAL modulator 1". 

Further reading