NCAPH


NCAPH
Non-SMC condensin I complex, subunit H
Identifiers
Symbols NCAPH; BRRN1; CAP-H; HCAP-H
External IDs OMIM602332 MGI2444777 HomoloGene5320 GeneCards: NCAPH Gene
RNA expression pattern
PBB GE NCAPH 212949 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 23397 215387
Ensembl ENSG00000121152 ENSMUSG00000034906
UniProt Q15003 Q6ZQJ9
RefSeq (mRNA) NM_015341 NM_144818.3
RefSeq (protein) NP_056156 NP_659067.2
Location (UCSC) Chr 2:
97 – 97.04 Mb
Chr 2:
126.93 – 126.96 Mb
PubMed search [1] [2]

Condensin complex subunit 2 also known as chromosome-associated protein H (CAP-H) or non-SMC condensin I complex subunit H (NCAPH) is a protein that in humans is encoded by the NCAPH gene.[1][2] CAP-H is a subunit of condensin I, a large protein complex involved in chromosome condensation

Function

CAP-H is a member of the barr protein family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. CAP-H is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization.[2]

References

  1. ^ Cabello OA, Baldini A, Bhat M, Bellen H, Belmont JW (Feb 1998). "Localization of BRRN1, the human homologue of Drosophila barr, to 2q11.2". Genomics 46 (2): 311–3. doi:10.1006/geno.1997.5021. PMID 9417923. 
  2. ^ a b "Entrez Gene: NCAPH non-SMC condensin I complex, subunit H". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23397. 

Further reading


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